State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China.
Wuhan University of Technology Advanced Engineering Technology Research Institute of Zhongshan City, Zhongshan 528400, China.
J Mater Chem B. 2024 Jun 5;12(22):5377-5390. doi: 10.1039/d4tb00411f.
The healing of scalded wounds faces many challenges such as chronic inflammation, oxidative stress, wound infection, and difficulties in vascular and nerve regeneration. Treating a single problem cannot effectively coordinate the complex regenerative microenvironment of scalded wounds, limiting the healing and functional recovery of the skin. Therefore, there is a need to develop a multi-effect treatment plan that can adaptively address the issues at each stage of wound healing. In this study, we propose a scheme for on-demand release of hydrogen sulfide (HS) based on the concentration of reactive oxygen species (ROS) in the wound microenvironment. This is achieved by encapsulating peroxythiocarbamate (PTCM) in the ROS-responsive polymer poly(ethylene glycol)-poly(L-methionine) (PMet) to form nanoparticles, which are loaded into a thermosensitive injectable hydrogel, F127-poly(L-aspartic acid--hydroxysuccinimide) (F127-P(Asp-NHS)), to create a scald dressing. The HS released by the hydrogel dressing on demand regulates the wound microenvironment by alleviating infection, reducing oxidative stress, and remodeling inflammation, thereby accelerating the healing of full-thickness scalded wounds. This hydrogel dressing for the adaptive release of HS has great potential in addressing complex scalded wounds associated with infection and chronic inflammation.
烫伤创面的愈合面临诸多挑战，如慢性炎症、氧化应激、创面感染以及血管和神经再生困难等。单一问题的治疗并不能有效协调烫伤创面复杂的再生微环境，限制了皮肤的愈合和功能恢复。因此，需要开发一种多效治疗方案，以适应创面愈合各阶段的问题。在本研究中，我们提出了一种基于创面微环境中活性氧（ROS）浓度的按需释放硫化氢（HS）方案。该方案通过将过氧硫代氨基甲酸盐（PTCM）包封在 ROS 响应性聚合物聚乙二醇-聚（L-甲硫氨酸）（PMet）中形成纳米颗粒，然后将其负载到温敏型可注射水凝胶 F127-聚（L-天冬氨酸-羟基琥珀酰亚胺）（F127-P（Asp-NHS））中，以制造一种烫伤敷料。水凝胶敷料按需释放的 HS 通过缓解感染、减轻氧化应激和重塑炎症来调节创面微环境，从而加速全层烫伤创面的愈合。这种用于 HS 自适应释放的水凝胶敷料在解决与感染和慢性炎症相关的复杂烫伤创面方面具有巨大潜力。
