妊娠特异性β1-糖蛋白的颗粒计数免疫测定法（PACIA），一种可能的多种恶性肿瘤和克罗恩氏回肠炎标志物。

Particle-counting immunoassay (PACIA) of pregnancy-specific beta 1-glycoprotein, a possible marker of various malignancies and Crohn's ileitis.

作者信息

Fagnart O C, Mareschal J C, Cambiaso C L, Masson P L

出版信息

Clin Chem. 1985 Mar;31(3):397-401.

Abstract

Pregnancy-specific beta 1-glycoprotein (SP1) was assayed by particle-counting immunoassay (PACIA) with a sensitivity of 1 microgram/L. In serum from 50 men, the SP1 concentration was less than 1 microgram/L, whereas three of the specimens from 46 nonpregnant women had values exceeding 1 microgram/L. In 29% of 950 consecutive patients' sera, SP1 concentrations exceeded 1 microgram/L--in sarcoma (six of six), in malignant hemopathies (101/127, 80%) such as myeloma (20/26, 92%) and acute myeloblastic leukemia (23/27, 90%), and in various other types of cancer (11/19, 58%) except for bronchial epithelioma, which did not lead to any significant increase of SP1 in the five patients examined. The concentration of SP1 was also frequently increased in patients with Crohn's ileitis (28/43, 65%) but not in patients with other inflammatory disorders.

摘要

采用粒子计数免疫分析（PACIA）法检测妊娠特异性β1-糖蛋白（SP1），灵敏度为1微克/升。在50名男性的血清中，SP1浓度低于1微克/升，而46名未怀孕女性的标本中有3份的值超过1微克/升。在950例连续患者的血清中，29%的患者SP1浓度超过1微克/升——肉瘤患者（6例中的6例）、恶性血液病患者（127例中的101例，80%），如骨髓瘤患者（26例中的20例，92%）和急性髓细胞白血病患者（27例中的23例，90%），以及除支气管上皮瘤外的其他各种癌症患者（19例中的11例，58%），在所检查的5例支气管上皮瘤患者中，SP1未出现任何显著升高。克罗恩回肠炎患者（43例中的28例，65%）的SP1浓度也经常升高，但其他炎症性疾病患者未出现这种情况。