Mochizuki M, Nussenblatt R B, Kuwabara T, Gery I
Invest Ophthalmol Vis Sci. 1985 Feb;26(2):226-32.
Five immunosuppressive and anti-inflammatory agents were tested for their effects on development of experimental autoimmune uveoretinitis (EAU) and immune responses to S-antigen in rats immunized with this retinal antigen. When administered daily from day 0-14 after immunization, cyclosporine at 5-20 mg/Kg was nontoxic and yet effective in inhibiting the development of EAU for at least 30 days. All other tested drugs were found toxic at their immunosuppressive doses. Of these drugs, only cyclophosphamide (at 5-20 mg/Kg) was capable of inhibiting EAU in some of the treated rats for up to 30 days. Other agents, bredinin (40-100 mg/Kg), dexamethasone (0.2-0.4 mg/Kg), or colchicine (0.5 mg/Kg) produced only a delay in the disease onset. Cyclosporine was also unique in its effect on the immune responses of the rats by selectively inhibiting only the specific T-cell-mediated responses to S-antigen (delayed skin response and lymphocyte response in culture), while having no negative effect on antibody production or the lymphocyte response to the polyclonal mitogen, concanavalin A. Other drugs, when effective, inhibited all types of immune response. In addition, cyclosporine was capable of preventing EAU even when given to rats as late as from day 7 after immunization. Only cyclophosphamide (at 20 mg/Kg/day) had a similar effect on 1/3 of the rats, while other drugs only delayed or had no effect on the disease onset when given by this late schedule.
测试了五种免疫抑制和抗炎药物对实验性自身免疫性葡萄膜视网膜炎（EAU）发展的影响以及对用这种视网膜抗原免疫的大鼠对S抗原的免疫反应的影响。在免疫后第0至14天每日给药时，5至20mg / Kg的环孢素无毒，但能有效抑制EAU发展至少30天。所有其他测试药物在其免疫抑制剂量下均有毒性。在这些药物中，只有环磷酰胺（5至20mg / Kg）能够在一些治疗的大鼠中抑制EAU长达30天。其他药物，布累迪宁（40至100mg / Kg）、地塞米松（0.2至0.4mg / Kg）或秋水仙碱（0.5mg / Kg）仅使疾病发作延迟。环孢素对大鼠免疫反应的影响也很独特，它仅选择性抑制对S抗原的特异性T细胞介导的反应（延迟皮肤反应和培养中的淋巴细胞反应），而对抗体产生或淋巴细胞对多克隆有丝分裂原刀豆球蛋白A的反应没有负面影响。其他药物在有效时会抑制所有类型的免疫反应。此外，环孢素即使在免疫后第7天给大鼠服用也能够预防EAU。只有环磷酰胺（20mg / Kg /天）对三分之一的大鼠有类似作用，而其他药物在按此较晚时间表给药时仅延迟疾病发作或对其没有影响。
