一项回顾性研究，旨在确定 HBV PreS1 抗原、HBV e 抗原、丙氨酸氨基转移酶和 HBV DNA 之间的相关性。

A retrospective study to determine the correlation among HBV PreS1 antigen, HBV e antigen, alanine aminotransferase, and HBV DNA.

机构信息

Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China; Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.

出版信息

Clin Res Hepatol Gastroenterol. 2024 Jun;48(6):102369. doi: 10.1016/j.clinre.2024.102369. Epub 2024 May 7.

DOI:10.1016/j.clinre.2024.102369

PMID:38719147

Abstract

BACKGROUND AND AIM

Hepatitis B virus (HBV) infection presents with indicators of varying clinical significance. We aimed to evaluate the correlation among HBV Pre-S1 antigen (HBV PreS1-Ag), HBV e antigen (HBeAg), HBV DNA, and alanine aminotransferase (ALT) levels.

METHODS

We retrospectively analyzed 6180 serum samples collected between 2020 and 2022 at the Shanghai General Hospital, China. Data regarding PreS1-Ag, HBeAg, ALT, and HBV DNA were compiled. Correlation analyses and cross-tabulations were employed to explore the diagnostic indicators.

RESULTS

The detection rates of both antigen indicators showed a proportional increase with HBV DNA loads. The correlation between PreS1-Ag and HBV DNA (r = 0.616) was stronger than that between HBeAg and HBV DNA (r = 0.391). The specificity of PreS1-Ag (84.30 %) was lower than that of HBeAg (97.44 %), whereas the sensitivity of HBeAg (91.13 %) significantly surpassed that of PreS1-Ag (29.56 %). Among the HBV DNA positive patients, 92.04 % tested positive for at least one indicator, which exceeded the rate of PreS1+HBeAg- and PreS1-HBeAg+ (52. 28 % and 68. 56 %, respectively). Only 1.75 % of the patients exhibited double negativity, which was lower than the percentage of patients with single negativity (1.95 % and 12.00 % for PreS1-Ag and HBeAg, respectively). The PreS1 levels correlated with ALT levels (r = 0.317); patients with PreS1-positive status had higher ALT levels than patients with PreS1-negative status.

CONCLUSION

PreS1-Ag is a more robust HBV replication indicator than HBeAg. PreS1-Ag displayed high sensitivity, whereas HBeAg demonstrated high specificity. Moreover, PreS1-Ag levels correlated with ALT levels. A combination of these indicators demonstrated dependable clinical value for detecting HBV infection and evaluating liver function.

摘要

背景与目的

乙型肝炎病毒（HBV）感染表现出不同临床意义的指标。我们旨在评估 HBV 前 S1 抗原（HBV PreS1-Ag）、乙型肝炎 e 抗原（HBeAg）、HBV DNA 和丙氨酸氨基转移酶（ALT）水平之间的相关性。

方法

我们回顾性分析了 2020 年至 2022 年期间在中国上海总医院采集的 6180 份血清样本。编译了 PreS1-Ag、HBeAg、ALT 和 HBV DNA 数据。采用相关性分析和交叉表进行分析，以探讨诊断指标。

结果

两种抗原指标的检测率均随 HBV DNA 负荷的增加而呈比例增加。PreS1-Ag 与 HBV DNA 之间的相关性（r = 0.616）强于 HBeAg 与 HBV DNA 之间的相关性（r = 0.391）。PreS1-Ag 的特异性（84.30%）低于 HBeAg（97.44%），而 HBeAg 的灵敏度（91.13%）明显高于 PreS1-Ag（29.56%）。在 HBV DNA 阳性患者中，至少有一个指标阳性的患者占 92.04%，超过了 PreS1+HBeAg-和 PreS1-HBeAg+的比例（分别为 52.28%和 68.56%）。只有 1.75%的患者表现为双重阴性，低于单一阴性的比例（PreS1-Ag 和 HBeAg 分别为 1.95%和 12.00%）。PreS1 水平与 ALT 水平相关（r = 0.317）；PreS1 阳性患者的 ALT 水平高于 PreS1 阴性患者。