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印度高血压患者当前特征和治疗趋势登记研究(RECORD):真实世界观察研究的最终结果。

The Indian REgistry on Current Patient PrOfiles and TReatment TrenDs in Hypertension (RECORD): Final Outcomes of the Real-world Observational Study.

机构信息

Professor and Unit Head, Department of Medicine, Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital, Mumbai, Maharashtra, India.

Additional Professor Medical Superintendent, Department of Medicine, King George's Medical University, India.

出版信息

J Assoc Physicians India. 2023 Nov;71(11):43-49. doi: 10.59556/japi.71.0399.

Abstract

: The Indian Registry on Current Patient Profiles and Treatment Trends in Hypertension (Record) evaluated the current trends and outcomes related to hypertension (HTN) management at 3, 6, 12, and 24 months in India. This study highlights and evaluates the outcomes and trends noted at 24 months. : The detailed study methodology is provided in the earlier publication (interim analysis at 12 months). Aspects such as changes in the quality of life (QOL), percentage of patients reaching target blood pressure (BP), treatment pattern among patients with comorbid conditions, and difference in treatment patterns between public and private healthcare settings, at 24 months, were evaluated in the current study. : The study population included 2,000 patients (55.7% males) with a mean age of 54.45 years. Telmisartan (43.7%) and amlodipine + telmisartan (16.4%) were the most prescribed monotherapy and combination therapy among patients with newly diagnosed HTN. A significant decrease in both systolic BP (SBP) and diastolic BP (DBP) was noted in the overall patient population at 24 months ( < 0.001). The mean change in SBP and DBP was slightly higher at 24 months compared to 12 months. This was more evident among patients on combination therapy. A significant improvement in QOL was noted at 24 months. : Treatment strategies in HTN management are changing and are associated with effective HTN control and improvements in QOL. However, there is a further need for improved awareness regarding the optimal usage of combination therapy for better management of uncontrolled HTN. : Rajadhyaksha GC, Reddy H, Singh AK, The Indian REgistry on Current Patient PrOfiles and TReatment TrenDs in Hypertension (RECORD): Final Outcomes of the Real-World Observational Study. J Assoc Physicians India 2023;71(11):43-49.

摘要

印度当前患者特征和高血压治疗趋势登记(RECORD)评估了印度高血压管理在 3、6、12 和 24 个月的当前趋势和结果。本研究重点评估了 24 个月时的结果和趋势。本研究还评估了 24 个月时患者的生活质量(QOL)变化、达到目标血压的患者比例、合并症患者的治疗模式以及公共和私人医疗保健环境之间的治疗模式差异等方面。研究人群包括 2000 名新诊断为高血压的患者(55.7%为男性),平均年龄为 54.45 岁。替米沙坦(43.7%)和氨氯地平+替米沙坦(16.4%)是新诊断为高血压的患者中最常开的单药和联合治疗药物。在 24 个月时,整体患者人群的收缩压(SBP)和舒张压(DBP)均显著下降(<0.001)。与 12 个月相比,24 个月时 SBP 和 DBP 的平均变化略高。这在联合治疗的患者中更为明显。24 个月时 QOL 显著改善。高血压管理的治疗策略正在发生变化,与有效控制高血压和改善 QOL 相关。然而,仍需要进一步提高对联合治疗最佳使用的认识,以更好地管理未控制的高血压。Rajadhyaksha GC,Reddy H,Singh AK,印度当前患者特征和高血压治疗趋势登记(RECORD):真实世界观察研究的最终结果。印度医师协会杂志 2023;71(11):43-49。

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