貌似登革热实则噬血细胞性淋巴组织细胞增生症。

Apparent Dengue Fever Turned Out to be Hemophagocytic Lymphohistiocytosis.

机构信息

Associate Professor, Department of Medicine, Medical College, The Maharaja Sayajirao University, Baroda, Gujarat, India, Corresponding Author.

Senior Resident, Department of Medicine, Medical College, The Maharaja Sayajirao University, Baroda, Gujarat, India.

出版信息

J Assoc Physicians India. 2023 Nov;71(11):96-99. doi: 10.59556/japi.71.0387.

DOI:10.59556/japi.71.0387

PMID:38720506

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an extremely uncommon hematologic condition that is potentially fatal. It is a disease of histiocyte or lymphocyte hyperactivity, which can be inherited (primary) or acquired (secondary). Dengue fever and HLH both can present with fever, lethargy, and a blood profile of pancytopenia, which makes it difficult to diagnose HLH promptly in a region with dengue endemicity. Clinical and supportive biochemistry findings help clinicians to suspect and diagnose HLH. This article presents a case report of a patient who was diagnosed with dengue fever during initial presentation with subsequent swerves toward HLH. Diagnosing HLH associated with dengue can be difficult. However, it is of utmost importance to diagnose it early, as an early diagnosis and management can lead to significantly improved outcomes. : Gandhi A, Patel P, Shah D. Apparent Dengue Fever Turned Out to be Hemophagocytic Lymphohistiocytosis. J Assoc Physicians India 2023;71(11):96-99.

摘要

噬血细胞性淋巴组织细胞增生症（HLH）是一种极罕见的血液系统疾病，具有潜在致命性。它是一种组织细胞或淋巴细胞活性亢进的疾病，可分为遗传性（原发性）或获得性（继发性）。登革热和 HLH 都可能出现发热、乏力和全血细胞减少的血液学特征，这使得在登革热流行地区很难及时诊断 HLH。临床和支持性生化检查结果有助于临床医生怀疑和诊断 HLH。本文报告了一例患者，最初表现为登革热，随后病情转向 HLH。诊断与登革热相关的 HLH 可能具有挑战性。然而，早期诊断非常重要，因为早期诊断和治疗可以显著改善预后。