获得性巨核细胞血小板减少症误诊为血清阴性关节炎患者的免疫性血小板减少症：病例报告。

Acquired Amegakaryocytic Thrombocytopenia Misdiagnosed as Immune Thrombocytopenia in a Patient with Seronegative Arthritis: A Case Report.

机构信息

Professor and HOD, Department of General Medicine, Shri Atal Bihari Vajpayee Medical College and Research Institute, Bengaluru, Karnataka, India.

Assistant Professor, Department of General Medicine, Shri Atal Bihari Vajpayee Medical College and Research Institute, Bengaluru, Karnataka, India.

出版信息

J Assoc Physicians India. 2023 Nov;71(11):100-102. doi: 10.59556/japi.71.0386.

DOI:10.59556/japi.71.0386

PMID:38720507

Abstract

Acquired amegakaryocytic thrombocytopenia (AATP) is an uncommon cause of severe thrombocytopenia with preserved cells of other lineages, which can present with severe bleeding episodes. We report a case of a 45-year-old male with seronegative arthritis who was diagnosed with idiopathic thrombocytopenic purpura (ITP) and was being treated with steroids for ITP. Despite aggressive treatment, the patient had persistently low levels of platelets. In view of persistent thrombocytopenia, bone marrow biopsy was done and was diagnosed as Acquired Amegakaryocytic Thrombocytopenia (AATP). Patient was successfully treated with cyclosporine. Correct identification of AATP is essential because it can lead to life threatening bleeding manifestations and advance into Aplastic anemia or MDS. : N AM, Rajanna AH, Kamath N. Acquired Amegakaryocytic Thrombocytopenia Misdiagnosed as Immune Thrombocytopenia in a Patient with Seronegative Arthritis: A Case Report. J Assoc Physicians India 2023;71(11):100-102.

摘要

获得性巨核细胞血小板减少症（AATP）是一种罕见的以其他谱系细胞数量正常为特征的严重血小板减少症，可导致严重出血事件。我们报告了一例 45 岁男性，患有血清阴性关节炎，被诊断为特发性血小板减少性紫癜（ITP），并正在接受 ITP 的类固醇治疗。尽管进行了积极治疗，但患者的血小板水平持续较低。鉴于持续性血小板减少症，进行了骨髓活检，诊断为获得性巨核细胞血小板减少症（AATP）。患者成功接受了环孢素治疗。正确识别 AATP 至关重要，因为它可能导致危及生命的出血表现，并进展为再生障碍性贫血或 MDS。