硝酸镓的临床毒理学和药理学研究。
Clinical toxicologic and pharmacologic studies of gallium nitrate.
作者信息
Krakoff I H, Newman R A, Goldberg R S
出版信息
Cancer. 1979 Nov;44(5):1722-7. doi: 10.1002/1097-0142(197911)44:5<1722::aid-cncr2820440528>3.0.co;2-c.
Abstract
Gallium nitrate, administered intravenously to patients with advanced cancer, produced renal functional abnormalities consistently at a dose of 750 mg/m2. The toxicity at that dose could be modified by fluid loading and osmotic diuresis. Pharmacokinetic studies revealed a biphasic half-life, (T 1/2 alpha = 87 minutes and T 1/2 beta = 24.5 hours). Osmotic diuresis reduced the urinary concentration of gallium but did not affect serum levels or clearance.
摘要
硝酸镓静脉注射给晚期癌症患者时，剂量为750mg/m²时会持续产生肾功能异常。该剂量下的毒性可通过补液和渗透性利尿来减轻。药代动力学研究显示出双相半衰期，（α相半衰期=87分钟，β相半衰期=24.5小时）。渗透性利尿降低了尿中镓的浓度，但不影响血清水平或清除率。
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