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警惕免疫疗法的毒性:一例由伊匹单抗/纳武单抗治疗引起的单侧上睑下垂病例。

Keeping an Eye Out for Immunotherapy Toxicity: A Case of Unilateral Ptosis Caused by Ipilimumab/Nivolumab Therapy.

作者信息

Jazieh Khalid, Kottschade Lisa, Dimou Anastasios

机构信息

Division of Oncology, Mayo Clinic, Rochester, MN, USA.

出版信息

J Immunother Precis Oncol. 2024 May 2;7(2):126-129. doi: 10.36401/JIPO-23-44. eCollection 2024 May.

Abstract

Despite ocular adverse events from immune checkpoint inhibitors being uncommon, they are still important complications to be aware of. We present the case of metastatic melanoma on ipilimumab/nivolumab in a patient who developed immunotherapy complications with delayed diagnosis because the only presenting symptom was unilateral ptosis. We reviewed the literature for relevant and important ocular and neurological complications of immune checkpoint inhibitors.

摘要

尽管免疫检查点抑制剂引起的眼部不良事件并不常见,但它们仍然是需要注意的重要并发症。我们报告了一例接受伊匹单抗/纳武单抗治疗的转移性黑色素瘤患者,该患者出现了免疫治疗并发症,但诊断延迟,因为唯一的症状是单侧上睑下垂。我们查阅了相关文献,了解免疫检查点抑制剂的重要眼部和神经并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d59/11075476/0007dac1e11c/i2590-017X-7-2-126-f01.jpg

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