Liedl Bernard, Dodi Giuseppe, Inoue Hiromi, Neuman Menahem, Del Amo Elisabeth
Centre for Reconstructive Urogenital Surgery, Urology Clinic Munich, Planegg, Germany.
Department of Colorectal Surgery, University of Padova, Padova, Italy.
Ann Transl Med. 2024 Apr 22;12(2):23. doi: 10.21037/atm-23-1877. Epub 2024 Apr 18.
The structural basis of the Integral Theory is holistic. Four main pelvic muscles interact holistically with five main pelvic ligaments to maintain pelvic organ structure and function. The vagina is structurally weak. The support it provides to the bladder base is contingent on being stretched by opposite pelvic muscle forces, much like a trampoline. Its main role is to transmit muscle forces to facilitate continence, evacuation and control of urgency. Therefore, as an organ that cannot regenerate, the vagina should be conserved, and not excised. The ligaments provide the main structural support for the organs and are the most vulnerable part of the anatomical system to injury because their structural collagen is depolymerized prior to labour, and stretched during labour. Further ligament weakening occurs after menopause due to collagen breakdown. Hence, collagen loss is the main cause of organ prolapse and lower urinary tract symptoms (LUTS). The strengthening of damaged ligaments, whether surgically or non-surgically, can improve or cure symptoms and prolapse. Because collagen loss in ligaments is a principal cause of dysfunction in older women, collagen-creating techniques are advised: precisely inserted tapes to create neoligaments, or wide-bore No. 2 or No. 3 polyester ligament sutures instead of dissolvable sutures.
整体理论的结构基础是整体性的。四块主要的盆底肌肉与五条主要的盆底韧带相互作用,以维持盆腔器官的结构和功能。阴道在结构上较为薄弱。它对膀胱底部的支撑取决于是否被相反方向的盆底肌肉力量拉伸,这很像蹦床。其主要作用是传递肌肉力量以促进控尿、排空和控制尿急。因此,作为一个无法再生的器官,阴道应该被保留,而不是切除。韧带为器官提供主要的结构支撑,并且是解剖系统中最易受伤的部分,因为其结构中的胶原蛋白在分娩前会解聚,并在分娩过程中被拉伸。绝经后,由于胶原蛋白分解,韧带会进一步变弱。因此,胶原蛋白流失是器官脱垂和下尿路症状(LUTS)的主要原因。无论是通过手术还是非手术方式加强受损的韧带,都可以改善或治愈症状及脱垂。由于韧带中的胶原蛋白流失是老年女性功能障碍的主要原因,建议采用生成胶原蛋白的技术:精确植入带子以形成新韧带,或者使用2号或3号宽口径聚酯韧带缝线而非可溶解缝线。