Long Island University College of Veterinary Medicine, Greenvale, NY, USA.
Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA.
J Vet Diagn Invest. 2024 Jul;36(4):543-546. doi: 10.1177/10406387241252815. Epub 2024 May 9.
A 7-y-old, castrated male, leucistic sugar glider () was presented because of a progressive history of lethargy, ataxia, diarrhea, and anorexia. Abdominal ultrasound revealed fluid in the abdomen and an infiltrative mass in the liver. Due to a poor prognosis, euthanasia was performed. Postmortem examination revealed a focally extensive, infiltrative, off-white, firm mass in the liver with adhesion to the omentum, mesentery, gastric serosa, and diaphragm. The remaining hepatic parenchyma was diffusely yellow. Histologically, the hepatic mass was consistent with metastatic cholangiocarcinoma (cholangiocellular carcinoma) with proliferation of neoplastic epithelial cells surrounded by marked desmoplasia. Neoplastic cells expanded and infiltrated the adjacent omentum, mesentery, and the serosal surfaces of the stomach, kidney, and small and large intestines. To our knowledge, cholangiocarcinoma has not been reported previously in a sugar glider.
一只 7 岁去势雄性白变砂糖袋鼠（）因嗜睡、共济失调、腹泻和厌食的进行性病史而被送诊。腹部超声显示腹部有液体和肝脏浸润性肿块。由于预后不良，实施了安乐死。尸检显示肝脏有一处广泛浸润、灰白色、坚硬的肿块，与大网膜、肠系膜、胃浆膜和横膈膜粘连。其余的肝实质呈弥漫性黄色。组织学上，肝肿块符合转移性胆管癌（胆管细胞癌），肿瘤上皮细胞增殖，周围有明显的纤维组织增生。肿瘤细胞扩张并浸润相邻的大网膜、肠系膜以及胃、肾和小肠、大肠的浆膜表面。据我们所知，胆管癌以前在砂糖袋鼠中没有被报道过。
