Suedmeyer Wm Kirk, Johnson Gayle
Kansas City Zoo, 6800 Zoo Drive, Kansas City, Missouri 64132, USA.
J Zoo Wildl Med. 2007 Jun;38(2):231-9. doi: 10.1638/1042-7260(2007)038[0231:SONIRK]2.0.CO;2.
An increase in the proportion of cases with neoplasia observed in a collection of captive red kangaroos (Macropus rufus) when compared with historical records and the paucity of reported neoplasms in kangaroos in the literature prompted a 10-yr review of all red kangaroo necropsies. Individual necropsy, medical, and inventory records for all kangaroos at the Kansas City Zoo were reviewed for the period 1 January 1992 to 31 December 2002. Two squamous cell carcinomas of the oral cavity, two mammary gland adenocarcinomas, a multicentric T-cell lymphosarcoma, and one submucosal pyloric lipoma were diagnosed in six of 28 kangaroo deaths. Three neoplasms were diagnosed antemortem. Four of the six neoplasms were considered malignant, and all four had metastasized. The mean age at death was 11 yr. All six animals with neoplasms were female; however, the exhibit population was composed solely of females. Only 11 cases of neoplasia in red kangaroos have been reported in the literature. On the basis of these cases and a review of the literature, the most commonly observed neoplasms in red kangaroos are mammary gland adenocarcinomas and oral squamous cell carcinomas. Common denominators were not identified in these cases, although chronic gingivitis could have been a contributing factor in the development of the oral squamous cell carcinomas.
与历史记录相比，圈养红袋鼠（大赤袋鼠）群体中观察到的肿瘤病例比例有所增加，且文献中报道的袋鼠肿瘤病例较少，这促使对所有红袋鼠尸体剖检进行了为期10年的回顾。对堪萨斯城动物园1992年1月1日至2002年12月31日期间所有袋鼠的个体尸体剖检、医疗和库存记录进行了审查。在28只死亡袋鼠中的6只身上诊断出2例口腔鳞状细胞癌、2例乳腺腺癌、1例多中心T细胞淋巴肉瘤和1例黏膜下幽门脂肪瘤。3例肿瘤在死前被诊断出来。6例肿瘤中有4例被认为是恶性的，且全部4例都已转移。死亡时的平均年龄为11岁。所有6只患肿瘤的动物均为雌性；然而，展出群体仅由雌性组成。文献中仅报道了11例红袋鼠肿瘤病例。基于这些病例并查阅文献，红袋鼠中最常观察到的肿瘤是乳腺腺癌和口腔鳞状细胞癌。尽管慢性牙龈炎可能是口腔鳞状细胞癌发生的一个促成因素，但在这些病例中未发现共同特征。
