Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
Department of Cognitive Science and Artificial Intelligence, Tilburg University, Tilburg, The Netherlands.
Brain Imaging Behav. 2024 Oct;18(5):989-1000. doi: 10.1007/s11682-024-00886-7. Epub 2024 May 9.
Patients with meningiomas frequently exhibit impairments in executive functioning. There are few studies specifically examining the role of frontal meningioma localization in executive functioning impairments. This study examines whether frontally located meningiomas are specifically associated with executive functioning impairments in a large sample of meningioma patients before treatment, using an axis-wise and lobe-based approach to meningioma localization. We retrospectively examined cognitive performances in 353 patients with frontal, frontally-involved and non-frontal meningiomas on a battery of tests including tests of executive functioning. We applied an axis-based approach to meningioma location, in addition to qualitative lobe-based localization. We examined the association between meningioma coordinates on an anterior-posterior axis and continuous cognitive performance scores in univariate correlations and linear regression analyses. We also examined the association between meningioma coordinates on an anterior-posterior axis with cognitive impairments in multivariable logistic regression analyses. Meningioma position on the anterior-posterior axis was only univariately associated with mean performance on the Stroop test Interference ratio and Symbol Digit Coding task. There was no (multivariable) association with impairments on tests of executive or non-executive domains. Increased odds of impairment on executive functioning tasks were associated with left-localization (Verbal Fluency) and larger meningioma volumes (Shifting Attention). We did not find a specific relation between a frontal meningioma location and executive functioning impairments, which may be explained by widespread organization of executive functioning throughout the brain, diffuse cognitive effects of the mass of meningiomas, functional reorganization due to neuroplasticity, or functional involvement of less-anteriorly located frontal areas.
脑膜瘤患者常表现出执行功能障碍。很少有研究专门研究额部脑膜瘤定位与执行功能障碍之间的关系。本研究采用轴位和叶位相结合的脑膜瘤定位方法，在治疗前对大量脑膜瘤患者进行了研究，以检查额部脑膜瘤是否与执行功能障碍有明确的关系。我们回顾性地检查了 353 名额叶、额部受累和非额叶脑膜瘤患者在一系列测试中的认知表现，包括执行功能测试。我们采用了轴位方法来定位脑膜瘤，除了定性的叶位定位。我们在单变量相关性和线性回归分析中，检查了脑膜瘤在前后轴上的位置与连续认知表现评分之间的关系。我们还在多变量逻辑回归分析中检查了脑膜瘤在前后轴上的位置与认知障碍之间的关系。前后轴上的脑膜瘤位置仅与 Stroop 测试干扰比和符号数字编码任务的平均表现呈单变量相关。与执行或非执行领域的障碍无相关性（多变量）。执行功能任务障碍的可能性增加与左侧定位（言语流畅性）和更大的脑膜瘤体积（转移注意力）有关。我们没有发现额叶脑膜瘤位置与执行功能障碍之间的特定关系，这可能是由于执行功能在大脑中广泛分布，脑膜瘤体积的弥漫性认知影响，神经可塑性导致的功能重组，或位于较前的额叶区域的功能参与。
