Arvaniti Christina K, Brotis Alexandros G, Karaferi Maria E, Benos Antonios D, Goupou Kerasia, Fountas Kostas N
Department of Neurosurgery, University Hospital of Larissa, Larissa, 41110, Greece.
School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Brain Spine. 2025 Aug 6;5:104383. doi: 10.1016/j.bas.2025.104383. eCollection 2025.
Meningiomas remain the most frequently occurring intracranial, extra-axial, space-occupying lesions. Aspects such as neurocognitive function and quality of life become more and more crucial. Several meningioma patients present with evidence of neurocognitive impairment, behavioral disorders, or even psychiatric symptoms.
This review synthesizes the current literature on neurocognitive evaluation in intracranial meningioma patients, focusing on the range of cognitive domains affected (Q1), the assessment tools utilized (Q2), and the relationship between tumor characteristics and cognitive outcomes (Q3).
A PRISMA-compliant systematic review was performed. We searched PubMed, Scopus, and Dimensions, to identify relevant studies published to date. Additionally, we examined the reference lists of the selected studies. The most recent literature search was conducted on January 31, 2025.
We included 30 studies. The neurocognitive domains examined encompass a range of functions, such as executive functioning, memory, attention, perceptual speed, visuospatial abilities, verbal fluency, cognitive flexibility, and cognitive function. The most frequently used tests as demonstrated in current literature are WAIS, RAVLT, WMS, TMT, Stroop test and CNS Vital signs. Tumor size, increased age, peritumoral edema and skull base meningiomas were all associated with worse performance in various cognitive domains.
Our analysis reveals that meningiomas can significantly impact cognitive function, affecting various domains such as memory, executive function, attention, and language. Most of these domains seem to improve postoperatively. A common battery test for neurocognitive evaluation in all meningioma patients would provide us with more comparable and reliable results.
脑膜瘤仍然是最常见的颅内、轴外占位性病变。神经认知功能和生活质量等方面变得越来越重要。一些脑膜瘤患者存在神经认知障碍、行为障碍甚至精神症状的证据。
本综述综合了目前关于颅内脑膜瘤患者神经认知评估的文献，重点关注受影响的认知领域范围（问题1）、所使用的评估工具（问题2）以及肿瘤特征与认知结果之间的关系（问题3）。
进行了一项符合PRISMA标准的系统综述。我们检索了PubMed、Scopus和Dimensions，以识别迄今为止发表的相关研究。此外，我们还查阅了所选研究的参考文献列表。最近一次文献检索于2025年1月31日进行。
我们纳入了30项研究。所检查的神经认知领域包括一系列功能，如执行功能、记忆、注意力、感知速度、视觉空间能力、语言流畅性、认知灵活性和认知功能。当前文献中最常用的测试是韦氏成人智力量表（WAIS）、雷伊听觉词语学习测验（RAVLT）、韦氏记忆量表（WMS）、连线测验（TMT）、斯特鲁普测验和中枢神经系统生命体征测试。肿瘤大小、年龄增长、瘤周水肿和颅底脑膜瘤均与各个认知领域的较差表现相关。
我们的分析表明，脑膜瘤可显著影响认知功能，影响记忆、执行功能、注意力和语言等多个领域。这些领域中的大多数在术后似乎有所改善。对所有脑膜瘤患者进行神经认知评估的通用成套测试将为我们提供更具可比性和可靠性的结果。
