设计 HIV-1 疫苗开发的增强免疫原。
Designing boosting immunogens for HIV-1 vaccine development.
机构信息
Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.
出版信息
Cell Host Microbe. 2024 May 8;32(5):632-634. doi: 10.1016/j.chom.2024.04.008.
PMID:38723601
Abstract
Inducing HIV-1 broadly neutralizing antibodies (bnAbs) through vaccination poses exceptional challenges. In this issue of Cell Host & Microbe, Wiehe and colleagues report the elicitation of affinity-matured bnAbs in knock-in mice through boosting immunogen vaccination, which selects for key improbable mutations.
摘要
通过疫苗接种诱导广泛中和 HIV-1 的抗体（bnAbs）带来了特殊的挑战。在本期《Cell Host & Microbe》中，Wiehe 及其同事报道了通过增强免疫原疫苗接种在基因敲入小鼠中引发亲和力成熟的 bnAbs，该方法选择了关键的不太可能出现的突变。
Zotero 插件