Scherlacher A, Jakse R, Lehnert M
Laryngol Rhinol Otol (Stuttg). 1985 Feb;64(2):58-61.
MTX 250 mg./m2 was administered via i.v. push, followed 1 hour later by a 5-Fu 600 mg./m2 i.v. push. 24 hours after methotrexate, oral leucovorin-rescue started with 15 mg. Every 6 hours for a total of 5 doses. The courses were repeated at weekly intervals, if the toxicity permitted such repetition. 28 patients could be evaluated for response. The overall response rate was 39.2%, with 17.8% (5/28) complete response. The mean duration of complete and partial remissions was 30,8 and 24 weeks, respectively. Subjectively, the patients tolerated the treatment very well. Objective toxicity was moderate, and the major side effect was a generally mild myelosuppression. Thus, in our experience, this regimen can be recommended in the palliative treatment of rSCCHN.
甲氨蝶呤（MTX）以静脉推注方式给药，剂量为250毫克/平方米，1小时后接着静脉推注5-氟尿嘧啶（5-Fu），剂量为600毫克/平方米。在甲氨蝶呤给药24小时后，开始口服亚叶酸钙解救，剂量为15毫克，每6小时一次，共5剂。如果毒性允许重复，则每隔一周重复疗程。28例患者可评估反应情况。总体缓解率为39.2%，完全缓解率为17.8%（5/28）。完全缓解和部分缓解的平均持续时间分别为30.8周和24周。主观上，患者对治疗耐受性良好。客观毒性为中度，主要副作用是普遍轻度的骨髓抑制。因此，根据我们的经验，该方案可推荐用于复发转移性头颈部鳞状细胞癌（rSCCHN）的姑息治疗。
