Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu, Korea.
J Med Primatol. 2024 Jun;53(3):e12701. doi: 10.1111/jmp.12701.
Stress profoundly affects physical and emotional well-being, extending its physiological influence to the female menstrual cycle, impeding the hypothalamus-pituitary-gonadal (HPG) axis, and affecting fertility by suppressing sex-stimulating hormones.
In this study, we meticulously analyzed menstrual cycles and corresponding hormonal fluctuations in three female Cynomolgus monkeys.
The preliminary findings indicated lower-than-normal levels of cortisol, follicle-stimulating hormone (FSH), and estradiol. Anovulatory bleeding occurred in one monkey, which could be linked to stress. In contrast to cortisol, alkaline phosphatase (ALP), which is correlated to cortisol levels, was consistently elevated in menstruating monkeys, suggesting its potential as a stress indicator. The non-menstruating group exhibited stress-related weight loss, emphasizing the observed ALP trends.
Non-menstruating monkeys may experience more stress than menstruating monkeys. The implications of this study extend beyond the confines of primate studies and offer a valuable method for enhancing the welfare of female Cynomolgus monkeys.
压力对身心健康有深远影响，其生理影响延伸至女性月经周期，抑制下丘脑-垂体-性腺（HPG）轴，并通过抑制性刺激激素来影响生育能力。
在这项研究中，我们详细分析了三只雌性食蟹猴的月经周期和相应的激素波动。
初步发现皮质醇、卵泡刺激素（FSH）和雌二醇水平低于正常水平。一只猴子出现无排卵性出血，这可能与压力有关。与皮质醇不同，碱性磷酸酶（ALP）与皮质醇水平相关，在经期猴子中持续升高，表明其可能作为压力指标。未经期组表现出与压力相关的体重减轻，强调了观察到的 ALP 趋势。
未经期的猴子可能比经期的猴子承受更多的压力。这项研究的意义不仅限于灵长类研究，还为提高雌性食蟹猴的福利提供了一种有价值的方法。
