Department of HIV Medicine, Guys and St Thomas' NHS Foundation Trust, London, UK.
Department of Ophthalmology, Guys and St Thomas' NHS Foundation Trust, London, UK.
HIV Med. 2024 Sep;25(9):1086-1090. doi: 10.1111/hiv.13656. Epub 2024 May 9.
People living with HIV are disproportionately represented among people with severe mpox. Mild and self-limiting conjunctival involvement has been well-documented, and severe ocular complications, including keratitis, corneal scarring, and the associated loss of vision, are increasingly recognized. Tecovirimat is the first-line antiviral therapy for severe mpox, but data around the efficacy of systemic antiviral agents for mpox are limited, particularly in cases of ocular mpox.
Here, we describe a case of sight-threatening necrotic blepharokeratoconjunctivitis in a person with advanced HIV, requiring an extended course of tecovirimat due to persistent mpox viral shedding for nearly 5 months.
患有 HIV 的人在患有严重猴痘的人群中比例过高。轻度和自限性的结膜受累已有充分记录，越来越多的人认识到严重的眼部并发症，包括角膜炎、角膜瘢痕形成以及相关的视力丧失。特考韦瑞是治疗严重猴痘的一线抗病毒药物，但关于系统抗病毒药物治疗猴痘的疗效的数据有限，特别是在眼部猴痘的情况下。
在这里，我们描述了一例晚期 HIV 患者发生严重的威胁视力的坏死性睑结膜炎角膜炎，由于近 5 个月持续有猴痘病毒脱落，需要延长特考韦瑞的疗程。
