依库珠单抗治疗阵发性夜间血红蛋白尿：两例成功妊娠结局病例
Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes.
作者信息
Ilic Jovanka, Pujic Borislava, Jakovljevic Branislava, Sekulic Borivoj, Agic Danijela, El Farra Amir, Micanovic Branimir, Vejnovic Tihomir, Urosevic Ivana, Savic Aleksandar
机构信息
Clinic оf Hematology Clinical Center оf Vojvodina Novi Sad Serbia.
Clinic of Anesthesia Intensive Care and Pain Therapy, Clinical Center оf Vojvodina Novi Sad Serbia.
出版信息
Clin Case Rep. 2024 May 8;12(5):e8900. doi: 10.1002/ccr3.8900. eCollection 2024 May.
Abstract
Paroxysmal nocturnal hemoglobinuria is a rare disease with the incidence ranging from 0.08 to 0.57 per 100,000 person-years. Up to 25% of cases in women are detected during pregnancy. We report two cases of successful pregnancy outcomes in patients treated with eculizumab, pointing out the importance of interdisciplinary approach in these high-risk pregnancies.
摘要
阵发性夜间血红蛋白尿是一种罕见疾病，发病率为每10万人年0.08至0.57例。高达25%的女性病例是在孕期发现的。我们报告了两例接受依库珠单抗治疗的患者成功妊娠的病例，指出了跨学科方法在这些高危妊娠中的重要性。
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本文引用的文献
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Adv Clin Exp Med. 2022 Jun;31(6):707-710. doi: 10.17219/acem/150600.
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Pregnancy with Paroxysmal Nocturnal Hemoglobinuria: A Case Series with Review of the Literature.阵发性睡眠性血红蛋白尿症合并妊娠：病例系列及文献复习
Saudi J Med Med Sci. 2021 May-Aug;9(2):178-189. doi: 10.4103/sjmms.sjmms_4_20. Epub 2021 Apr 29.
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The incidence and prevalence of patients with paroxysmal nocturnal haemoglobinuria and aplastic anaemia PNH syndrome: A retrospective analysis of the UK's population-based haematological malignancy research network 2004-2018.阵发性睡眠性血红蛋白尿症和再生障碍性贫血 PNH 综合征患者的发病率和患病率：英国基于人群的血液恶性肿瘤研究网络 2004-2018 年的回顾性分析。
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