Zamanian Mohammad Yasin, Golmohammadi Maryam, Vadiyan Filipp V, Almulla Ausama A, Vadiyan Diana E, Morozova Natalia S, Alkadir Ola Kamal A, Kareem Anaheed Hussein, Alijani Mojtaba
Department of Physiology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran.
Department of Pharmacology and Toxicology, School of Pharmacy Hamadan University of Medical Sciences Hamadan Iran.
Food Sci Nutr. 2024 Feb 16;12(5):3164-3176. doi: 10.1002/fsn3.4035. eCollection 2024 May.
Orthodontic tooth movement (OTM) is a critical process in dental alignment, driven by the application of calibrated orthodontic forces. This study delves into the intricate molecular and cellular mechanisms by which vitamin D3 influences OTM. Vitamin D3 is identified as a critical regulator in bone metabolism, enhancing osteoblast activity and bone formation while also modulating osteoclast quantity and RANKL expression, essential for the remodeling of the alveolar bone. The precise mechanisms through which vitamin D3 facilitates these processes are explored, highlighting its potential in accelerating bone remodeling and, consequently, tooth alignment. This comprehensive review underscores vitamin D3's anabolic impact on bone metabolism and its pivotal role in the synthesis and mineralization processes governed by osteoblasts. The findings illuminate vitamin D3's promise in augmenting orthodontic therapy, suggesting its utility in improving treatment efficiency and reducing duration. However, the need for further research into the optimal application of vitamin D3 in orthodontics is emphasized, particularly concerning dosage, timing, and delivery methods.
正畸牙齿移动（OTM）是牙齿排列中的一个关键过程，由校准的正畸力驱动。本研究深入探讨了维生素D3影响OTM的复杂分子和细胞机制。维生素D3被确定为骨代谢的关键调节因子，可增强成骨细胞活性和骨形成，同时还能调节破骨细胞数量和RANKL表达，这对牙槽骨重塑至关重要。研究探讨了维生素D3促进这些过程的精确机制，突出了其在加速骨重塑从而促进牙齿排列方面的潜力。这一全面综述强调了维生素D3对骨代谢的合成作用及其在成骨细胞主导的合成和矿化过程中的关键作用。研究结果揭示了维生素D3在增强正畸治疗效果方面的前景，表明其在提高治疗效率和缩短治疗时间方面的效用。然而，强调了需要进一步研究维生素D3在正畸中的最佳应用，特别是在剂量、时机和给药方法方面。
