基于 Olink 技术的靶向蛋白质组学的方法和临床生物标志物发现。
Methods and clinical biomarker discovery for targeted proteomics using Olink technology.
机构信息
Department of Clinical Epidemiology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Center for Cardiovascular and Cerebrovascular Epidemiology and Translational Medicine, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
出版信息
Proteomics Clin Appl. 2024 Sep;18(5):e2300233. doi: 10.1002/prca.202300233. Epub 2024 May 10.
PURPOSE
This paper is to offer insights for designing research utilizing Olink technology to identify biomarkers and potential therapeutic targets for disease treatment.
EXPERIMENTAL DESIGN
We discusses the application of Olink technology in oncology, cardiovascular, respiratory and immune-related diseases, and Outlines the advantages and limitations of Olink technology.
RESULTS
Olink technology simplifies the search for therapeutic targets, advances proteomics research, reveals the pathogenesis of diseases, and ultimately helps patients develop precision treatments.
CONCLUSIONS
Although proteomics technology has been rapidly developed in recent years, each method has its own disadvantages, so in the future research, more methods should be selected for combined application to verify each other.
目的
本文旨在为利用 Olink 技术设计研究提供见解，以鉴定疾病治疗的生物标志物和潜在治疗靶点。
实验设计
我们讨论了 Olink 技术在肿瘤学、心血管、呼吸和免疫相关疾病中的应用，并概述了 Olink 技术的优点和局限性。
结果
Olink 技术简化了治疗靶点的寻找，推进了蛋白质组学研究，揭示了疾病的发病机制，最终帮助患者开发出精准治疗方法。
结论
尽管蛋白质组学技术近年来发展迅速，但每种方法都有其自身的缺点，因此在未来的研究中，应选择更多的方法进行联合应用，以相互验证。
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