Department of Anatomy, Çukurova University Faculty of Medicine.
Department of Therapy and Rehabilitation, Vocational School of Health Services, Baskent University.
J Craniofac Surg. 2024 Jun 1;35(4):1284-1288. doi: 10.1097/SCS.0000000000010261. Epub 2024 May 10.
Cortical bone thickness is essential for the mechanical function of bone. Some factors including aging, sex, body size, hormone levels, behavior, and genetics lead to changes in cranial cortical robusticity. Moreover, the skull is one of the hardest and most durable structures in the human body. Schizophrenia is defined as a psychiatric disease characterized by delusions and hallucinations, and these patients have reduced brain volume; however, there is no study including cortical bone structure. For this reason, the aim of this study was to determine whether there is a difference in the skull cortical thickness of patients with schizophrenia and, compare it with healthy subjects. The cranial length, cranial width, anterior cortical thickness, right and left anterior cortical thickness, right and left lateral cortical thickness, right and left posterior lateral thickness, and posterior cortical thickness were measured with axial computed tomography images of 30 patients with schizophrenia and 132 healthy individuals aged between 18 and 69years. A statistically significant difference was found between the two groups in the measurements of right and left posterior lateral thickness, and posterior cortical thickness ( P = 0.006, P = 0.001, and P = 0.047, respectively). The sexes were compared, and it was found that the cranial width, anterior thickness, left anterior thickness, and right and left posterior thickness measurements of patients with schizophrenia showed a statistically significant difference compared with the control group ( P < 0.001, P = 0.003, P = 0.001, P < 0.001 and P < 0.001, respectively). The authors observed that skull cortical thickness may be different in schizophrenia. The results obtained from this study may be beneficial for evaluating these structures for clinical and pathological processes. Furthermore, knowledge about the skull cortical thickness in planning surgical procedures will increase the reliability and effectiveness of the surgical method, and this will minimize the risk of complications.
皮质骨厚度对于骨骼的力学功能至关重要。一些因素，包括年龄、性别、体型、激素水平、行为和遗传，导致颅皮质粗壮度发生变化。此外，颅骨是人体最坚硬、最耐用的结构之一。精神分裂症定义为一种以妄想和幻觉为特征的精神疾病，这些患者的大脑体积减小；然而，目前还没有研究包括皮质骨结构。出于这个原因，本研究旨在确定精神分裂症患者的颅骨皮质厚度是否存在差异，并将其与健康受试者进行比较。通过对 30 名精神分裂症患者和 132 名年龄在 18 至 69 岁之间的健康个体的轴向计算机断层扫描图像进行测量，得出颅长、颅宽、前皮质厚度、右侧和左侧前皮质厚度、右侧和左侧外侧皮质厚度、右侧和左侧后侧外侧厚度以及后皮质厚度。发现两组在右侧和左侧后侧外侧厚度和后皮质厚度的测量值上存在统计学差异（P=0.006、P=0.001 和 P=0.047）。比较了性别，发现与对照组相比，精神分裂症患者的颅宽、前厚度、左侧前厚度以及右侧和左侧后厚度的测量值存在统计学差异（P<0.001、P=0.003、P=0.001、P<0.001 和 P<0.001）。作者观察到，皮质骨厚度在精神分裂症中可能不同。本研究获得的结果可能有助于评估这些结构的临床和病理过程。此外，在规划手术过程中了解颅骨皮质厚度将提高手术方法的可靠性和有效性，并将最大限度地降低并发症风险。
