大鼠中血清素诱导的催乳素分泌受血管活性肠多肽（VIP）抗血清的抑制作用。

Inhibition by antiserum to vasoactive intestinal polypeptide (VIP) of prolactin secretion induced by serotonin in the rat.

作者信息

Ohta H, Kato Y, Shimatsu A, Tojo K, Kabayama Y, Inoue T, Yanaihara N, Imura H

出版信息

Eur J Pharmacol. 1985 Mar 12;109(3):409-12. doi: 10.1016/0014-2999(85)90404-2.

Abstract

Intraventricular (i.c.v.) injection of serotonin (5HT) or intravenous (i.v.) injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum. When the animals were injected i.c.v. or i.v. with specific anti-VIP rabbit serum, the plasma PRL responses to 5HT and 5HTP were blunted. These findings suggest that hypothalamic VIP is involved, at least in part, in PRL secretion induced by central serotonergic stimulation in the rat.

摘要

在预先用正常兔血清处理过的氨基甲酸乙酯麻醉大鼠中，脑室内（i.c.v.）注射5-羟色胺（5HT）或静脉内（i.v.）注射5HT的前体5-羟色氨酸（5HTP）可提高血浆催乳素（PRL）水平。当给动物脑室内或静脉内注射特异性抗血管活性肠肽（VIP）兔血清时，血浆PRL对5HT和5HTP的反应减弱。这些发现表明，下丘脑VIP至少部分参与了大鼠中枢5-羟色胺能刺激诱导的PRL分泌。