CAIDE 评分、阿尔茨海默病病理学与认知正常成年人认知的关系：CABLE 研究。

CAIDE Score, Alzheimer's Disease Pathology, and Cognition in Cognitively Normal Adults: The CABLE Study.

机构信息

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Shandong Xiehe University, Jinan, Shandong, China.

出版信息

J Alzheimers Dis. 2024;99(4):1273-1283. doi: 10.3233/JAD-240005.

DOI:10.3233/JAD-240005

PMID:38728186

Abstract

BACKGROUND

Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score serves as a credible predictor of an individual's risk of dementia. However, studies on the link of the CAIDE score to Alzheimer's disease (AD) pathology are scarce.

OBJECTIVE

To explore the links of CAIDE score to cerebrospinal fluid (CSF) biomarkers of AD as well as to cognitive performance.

METHODS

In the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, we recruited 600 cognitively normal participants. Correlations between the CAIDE score and CSF biomarkers of AD as well as cognitive performance were probed through multiple linear regression models. Whether the correlation between CAIDE score and cognitive performance was mediated by AD pathology was researched by means of mediation analyses.

RESULTS

Linear regression analyses illustrated that CAIDE score was positively associated with tau-related biomarkers, including pTau (p < 0.001), tTau (p < 0.001), as well as tTau/Aβ42 (p = 0.008), while it was in negative association with cognitive scores, consisting of MMSE score (p < 0.001) as well as MoCA score (p < 0.001). The correlation from CAIDE score to cognitive scores was in part mediated by tau pathology, with a mediation rate varying from 3.2% to 13.2%.

CONCLUSIONS

A higher CAIDE score, as demonstrated in our study, was linked to more severe tau pathology and poorer cognitive performance, and tau pathology mediated the link of CAIDE score to cognitive performance. Increased dementia risk will lead to cognitive decline through aggravating neurodegeneration.

摘要

背景

心血管危险因素、衰老和痴呆（CAIDE）风险评分可作为个体痴呆风险的可靠预测指标。然而，关于 CAIDE 评分与阿尔茨海默病（AD）病理之间联系的研究较少。

目的

探讨 CAIDE 评分与 AD 患者脑脊液（CSF）生物标志物以及认知表现之间的关系。

方法

在中国阿尔茨海默病生物标志物和生活方式（CABLE）研究中，我们招募了 600 名认知正常的参与者。通过多元线性回归模型探讨 CAIDE 评分与 AD 患者 CSF 生物标志物以及认知表现之间的相关性。通过中介分析研究 CAIDE 评分与认知表现之间的相关性是否通过 AD 病理学介导。

结果

线性回归分析表明，CAIDE 评分与 tau 相关生物标志物呈正相关，包括 pTau（p<0.001）、tTau（p<0.001）以及 tTau/Aβ42（p=0.008），而与认知评分呈负相关，包括 MMSE 评分（p<0.001）和 MoCA 评分（p<0.001）。CAIDE 评分与认知评分的相关性部分通过 tau 病理学介导，中介率为 3.2%至 13.2%。