Tan Shen, Zard Samir Z, Pham Le Nhan, Coote Michelle L, Banwell Martin G, Lan Ping, White Lorenzo V
Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Laboratoire de Synthèse Organique, CNRS, École Polytechnique, Palaiseau 91128, France.
Org Lett. 2024 May 24;26(20):4292-4296. doi: 10.1021/acs.orglett.4c01271. Epub 2024 May 10.
Here, we report a practical route to medicinally interesting lycorine congeners alongside formal syntheses of various lycorine-type natural products, including lycorine itself. The efficiency of our strategy derives from a back-to-back 5/6 radical cyclization sequence, which we systematically studied both experimentally and computationally. The results of our work will facilitate future development of urgently needed antiviral therapeutics based on lycorine.
在此，我们报告了一条通往具有药用价值的石蒜碱类似物的实用路线，同时还完成了包括石蒜碱本身在内的各种石蒜碱型天然产物的形式合成。我们策略的有效性源于一个连续的5/6自由基环化序列，我们对其进行了系统的实验和计算研究。我们的研究结果将推动基于石蒜碱的急需抗病毒疗法的未来发展。
