Department of Medicine, McMaster University, Hamilton, ON, Canada.
Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada.
Appl Physiol Nutr Metab. 2024 Sep 1;49(9):1271-1278. doi: 10.1139/apnm-2023-0572. Epub 2024 May 10.
A mother's intrauterine environment influences her health and that of her offspring, at birth and in the future. Herein, we present an overview of our Canadian Institutes of Health Research (CIHR)-funded grant "Understanding the impact of maternal and infant nutrition on infant/child health"-set within The NutriGen Birth Cohort Alliance. NutriGen is a consortium of four Canadian prospective birth cohorts representing >5000 mother-child pairs of diverse ethnic groups including South Asians, White Europeans, and Indigenous peoples. We summarize our objectives and main findings on outcomes of maternal diet, gestational diabetes, birth weight, cardiometabolic health, the microbiome, and epigenetic modifications. We append this work with 10 key messages when conducting multiethnic research and review our knowledge translation products. We describe the clinical impact of our research on maternal and child health and conclude with future directions on biomarker discovery, expansion to other ethnic groups, and interventions for high-risk populations.
母亲的宫内环境会影响她自身及其后代在出生时和未来的健康。在此，我们概述了加拿大卫生研究院（CIHR）资助的项目“了解母婴营养对婴儿/儿童健康的影响”-该项目是“营养基因出生队列联盟”的一部分。“营养基因”是一个由四个加拿大前瞻性出生队列组成的联盟，代表了包括南亚人、白欧洲人和土著人民在内的不同种族的>5000 对母婴对。我们总结了我们关于母亲饮食、妊娠糖尿病、出生体重、心脏代谢健康、微生物组和表观遗传修饰的研究目标和主要发现。我们将这方面的工作与进行多种族研究时的 10 条关键信息一起列出，并回顾了我们的知识转化产品。我们描述了我们的研究对母婴健康的临床影响，并就生物标志物发现、扩展到其他种族以及高危人群的干预措施方面提出了未来的方向。
