Rosen S T, Radvany R, Roenigk H, Terasaki P I, Bunn P A
J Am Acad Dermatol. 1985 Mar;12(3):531-4. doi: 10.1016/s0190-9622(85)70075-8.
Mycosis fungoides (MF) and Sézary syndrome (SS) are malignant non-Hodgkin's lymphomas, characterized by the proliferation of helper type T lymphocytes with a predilection for the skin. Because of the similarities in cytologic, histologic, cytogenetic, immunologic, and functional aspects of the malignant cells, as well as overlapping clinical features, these disorders are currently classified as cutaneous T cell lymphoma (CTCL). Though the etiology of these disorders remains obscure, environmental factors as well as viral infection have been implicated. In this study, seventy-six white patients with CTCL were typed for human leukocyte antigen (HLA)-A, -B, and -C to assess genetic susceptibility as determined by the major histocompatibility complex. An increase in the frequency of B8 and Bw35 was seen in SS patients but not in MF patients.
蕈样肉芽肿（MF）和塞扎里综合征（SS）是恶性非霍奇金淋巴瘤，其特征为辅助性T淋巴细胞增殖，且好发于皮肤。由于恶性细胞在细胞学、组织学、细胞遗传学、免疫学和功能方面存在相似性，以及临床特征重叠，这些疾病目前被归类为皮肤T细胞淋巴瘤（CTCL）。尽管这些疾病的病因仍不明确，但环境因素以及病毒感染与之有关。在本研究中，对76例CTCL白人患者进行了人类白细胞抗原（HLA）-A、-B和-C分型，以评估由主要组织相容性复合体决定的遗传易感性。在SS患者中观察到B8和Bw35频率增加，但在MF患者中未观察到。
