Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Thromb Haemost. 2024 Dec;124(12):1143-1151. doi: 10.1055/s-0044-1786819. Epub 2024 May 10.
The association between tea consumption and venous thromboembolism (VTE) remains unknown. We aimed to evaluate the association between tea consumption with different additives (milk and/or sweeteners) and incident VTE, and the modifying effects of genetic variation in caffeine metabolism on the association.
A total of 190,189 participants with complete dietary information and free of VTE at baseline in the UK Biobank were included. The primary outcome was incident VTE, including incident deep vein thrombosis and pulmonary embolism.
During a median follow-up of 12.1 years, 4,485 (2.4%) participants developed incident VTE. Compared with non-tea drinkers, tea drinkers who added neither milk nor sweeteners (hazard ratio [HR]: 0.85; 95% confidence interval [95% CI]: 0.76-0.94), only milk (HR: 0.86; 95% CI: 0.80-0.93), and both milk and sweeteners to their tea (HR: 0.90; 95% CI: 0.81-0.99) had a lower risk of VTE, while those who added only sweeteners to their tea did not (HR: 0.94; 95% CI: 0.75-1.17). Moreover, there was an L-shaped relationship between tea consumption and incident VTE among tea drinkers who added neither milk nor sweeteners, only milk, and both milk and sweeteners to their tea, respectively. However, a nonsignificant association was found among tea drinkers who added only sweeteners to their tea. Genetic variation in caffeine metabolism did not significantly modify the association (-interaction = 0.659).
Drinking unsweetened tea, with or without added milk, was associated with a lower risk of VTE. However, there was no significant association between drinking tea with sweeteners and incident VTE.
饮茶与静脉血栓栓塞症（VTE）之间的关联尚不清楚。我们旨在评估不同添加剂（牛奶和/或甜味剂）的茶的摄入与新发 VTE 之间的关联，并评估咖啡因代谢遗传变异对该关联的修饰作用。
在英国生物库中，共纳入了 190189 名在基线时无 VTE 且完整的饮食信息的参与者。主要结局是新发 VTE，包括新发深静脉血栓形成和肺栓塞。
在中位随访 12.1 年期间，4485 名（2.4%）参与者发生了新发 VTE。与不饮茶者相比，不添加牛奶和甜味剂的饮茶者（风险比 [HR]：0.85；95%置信区间 [95%CI]：0.76-0.94）、仅添加牛奶（HR：0.86；95%CI：0.80-0.93）以及同时添加牛奶和甜味剂的饮茶者（HR：0.90；95%CI：0.81-0.99）新发 VTE 的风险较低，而仅添加甜味剂的饮茶者（HR：0.94；95%CI：0.75-1.17）风险没有降低。此外，在不添加牛奶和甜味剂、仅添加牛奶以及同时添加牛奶和甜味剂的饮茶者中，茶的摄入量与新发 VTE 之间呈 L 形关系。然而，在仅添加甜味剂的饮茶者中，并未发现显著关联。咖啡因代谢遗传变异对该关联无显著修饰作用（-交互作用 = 0.659）。
饮用不加糖的茶，无论是否添加牛奶，与较低的 VTE 风险相关。然而，饮用加糖茶与新发 VTE 之间无显著关联。
