Department of Urology, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, 725 Albany Street, Suite 3B, Boston, MA 02118, USA.
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Building 115, Room 215, Maywood, IL 60153, USA.
Infect Dis Clin North Am. 2024 Jun;38(2):241-253. doi: 10.1016/j.idc.2024.03.003.
This article discusses the urinary microbiome in relation to urinary tract infection (UTI) in women. It makes biologic sense that the microbiota of different niches (bladder, vagina, and gut) interact with each other in health, as well as during a UTI event; however, these relationships remain poorly understood. Future research should close knowledge gaps regarding the interactions between the urinary microbiota and the host, amongst the microbiota of adjacent niches, and between the microbes within the same microbiota. The new knowledge should result in improved UTI treatment in the age of antibiotic stewardship.
本文讨论了女性尿路感染（UTI）与尿微生物组的关系。不同生态位（膀胱、阴道和肠道）的微生物组在健康状态以及 UTI 发病期间相互作用具有生物学意义，但这些关系仍知之甚少。未来的研究应缩小有关尿微生物组与宿主之间、相邻生态位的微生物组之间以及同一微生物组内微生物之间相互作用的知识空白。在抗生素管理时代，新知识应该会改善 UTI 的治疗效果。
