NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Department of Cardiac Surgery, Cardiovascular Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Sci Rep. 2024 May 10;14(1):10765. doi: 10.1038/s41598-024-59523-4.
The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5 T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to < 50%) and severe-ICAS (≥ 50%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance "low LDL-c-high LDL-p" group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55-5.00) in the reference of the concordance "low LDL-c-low LDL-p" group. This was followed by the concordance "high LDL-c-high LDL-p" group of 2.56 (1.69-3.85) and the discordance "high LDL-c-low LDL-p" group of 2.40 (1.29-4.46). These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.
《亚临床动脉粥样硬化的志贺流行病学研究》于 2006 年至 2008 年在日本滋贺县草津市进行。参与者通过核磁共振技术测量 LDL-p。740 名男性参加了随访，并于 2012 年至 2015 年进行了 1.5T 脑磁共振血管造影检查。参与者分为无 ICAS 组和 ICAS 组，ICAS 组包括任何检查动脉中轻度 ICAS（1 至<50%）和重度 ICAS（≥50%）。排除标准后，711 名男性被纳入分析，我们使用多因素逻辑回归分析血脂谱与 ICAS 患病率之间的关系。在研究参与者中，205 人（28.8%）有 ICAS，而 144 人（20.3%）表现出 LDL-c 和 LDL-p 水平不一致。在参考一致性“低 LDL-c-低 LDL-p”组中，不一致“低 LDL-c-高 LDL-p”组的 ICAS 风险最高，调整后的比值比（95%可信区间）为 2.78（1.55-5.00）。其次是一致性“高 LDL-c-高 LDL-p”组为 2.56（1.69-3.85）和不一致“高 LDL-c-低 LDL-p”组为 2.40（1.29-4.46）。这些发现表明，评估 LDL-p 水平与 LDL-c 水平相结合可能有助于识别 ICAS 风险较高的成年人。
