Li Zhenwei, Wu Yinzi, He Guannan, Wang Renzhi, Bao Xinjie
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Cancers (Basel). 2024 Apr 29;16(9):1731. doi: 10.3390/cancers16091731.
Phenotype transformation in pituitary neuroendocrine tumors is a little-known and unpredictable clinical phenomenon. Previous studies have not clearly defined and systematically concluded on the causes of this rare phenomenon. Additionally, the mechanisms of phenotype transformation are not well known. We reviewed cases reported in the literature with the aim of defining phenotype transformation in pituitary neuroendocrine tumors. We present an overview of the wide spectrum of phenotype transformation and its clinical features. We also discuss findings on the potential mechanism of this rare transformation, which may be related to PC1/3, the bioactivity of secretory hormones, gene mutations and the plasticity of pituitary neuroendocrine tumors. Clinicians should be aware of this rare phenomenon and more studies on the underlying mechanisms are required.
垂体神经内分泌肿瘤中的表型转化是一种鲜为人知且不可预测的临床现象。先前的研究尚未明确界定并系统总结这一罕见现象的成因。此外，表型转化的机制也尚不明确。我们回顾了文献中报道的病例，旨在明确垂体神经内分泌肿瘤中的表型转化。我们概述了广泛的表型转化及其临床特征。我们还讨论了关于这种罕见转化潜在机制的研究结果，其可能与PC1/3、分泌激素的生物活性、基因突变以及垂体神经内分泌肿瘤的可塑性有关。临床医生应意识到这一罕见现象，并且需要对其潜在机制进行更多研究。
