Hann H W, Stahlhut M W, Evans A E
Prog Clin Biol Res. 1985;175:331-45.
These studies suggest that a) the levels of serum ferritin are closely related to the prognosis of patients with neuroblastoma; b) the increased amounts of ferritin in the serum of patients with neuroblastoma are, in part, derived from the tumor; c) isoferritins from neuroblastoma cells exert adverse effects on the host immune response and host defenses; and d) therefore, isoferritins released from tumors may, in part, be responsible for the poor prognosis of patients with elevated levels of serum ferritin.
a）血清铁蛋白水平与神经母细胞瘤患者的预后密切相关；b）神经母细胞瘤患者血清中铁蛋白含量的增加部分源自肿瘤；c）神经母细胞瘤细胞的异铁蛋白对宿主免疫反应和宿主防御产生不利影响；d）因此，肿瘤释放的异铁蛋白可能在一定程度上导致血清铁蛋白水平升高的患者预后不良。
