Powojska Anna, Mystkowski Arkadiusz, Gundabattini Edison, Mystkowska Joanna
Department of Biomaterials and Medical Devices, Institute of Biomedical Engineering, Faculty of Mechanical Engineering, Bialystok University of Technology, Wiejska 45C, 15-351 Bialystok, Poland.
Department of Automatic Control and Robotics, Faculty of Electrical Engineering, Bialystok University of Technology, Wiejska 45D, 15-351 Bialystok, Poland.
Materials (Basel). 2024 Apr 24;17(9):1973. doi: 10.3390/ma17091973.
This paper verified the possibility of applying chitosan and/or ferulic acid or polycaprolactone (PCL)-based coatings to polydimethylsiloxane/neodymium-iron-boron (PDMS/NdFeB) composites using the spin-coating method. The surface modification of magnetic composites by biofunctional layers allows for the preparation of materials for biomedical applications. Biofunctional layered magnetic composites were obtained in three steps. The spin-coating method with various parameters (time and spin speed) was used to apply different substances to the surface of the composites. Scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) were used to analyze the thickness and surface topography. The contact angle of the obtained surfaces was tested. Increasing spin speed and increasing process time for the same speed resulted in decreasing the composite's thickness. The linear and surface roughness for the prepared coatings were approximately 0.2 μm and 0.01 μm, respectively, which are desirable values in the context of biocompatibility. The contact angle test results showed that both the addition of chitosan and PCL to PDMS have reduced the contact angle from 105° for non-coated composite to ~59-88° depending on the coating. The performed modifications gave promising results mainly due to making the surface hydrophilic, which is a desirable feature of projected biomaterials.
本文验证了使用旋涂法将壳聚糖和/或阿魏酸或聚己内酯（PCL）基涂层应用于聚二甲基硅氧烷/钕铁硼（PDMS/NdFeB）复合材料的可能性。通过生物功能层对磁性复合材料进行表面改性，可为生物医学应用制备材料。生物功能层状磁性复合材料分三步获得。采用具有不同参数（时间和转速）的旋涂法将不同物质涂覆在复合材料表面。使用扫描电子显微镜（SEM）和共聚焦激光扫描显微镜（CLSM）分析涂层厚度和表面形貌。测试所得表面的接触角。提高转速以及在相同转速下延长加工时间会导致复合材料涂层厚度减小。制备的涂层的线性粗糙度和表面粗糙度分别约为0.2μm和0.01μm，就生物相容性而言，这些都是理想的值。接触角测试结果表明，向PDMS中添加壳聚糖和PCL均会使接触角从未涂层复合材料的105°降低至约59 - 88°，具体取决于涂层类型。所进行的改性取得了有前景的结果，主要是因为使表面具有亲水性，这是预期生物材料的一个理想特性。
