Chair and Department of Medicinal Chemistry, Faculty of Pharmacy, The Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
A-Sense Sp. z o.o., Moscickiego 1, 24-100 Pulawy, Poland.
Molecules. 2024 Apr 27;29(9):2020. doi: 10.3390/molecules29092020.
The scientific article focuses on the role of azulene and its derivatives in the therapy of dermatological diseases, presenting the latest laboratory and clinical research as well as prospects for further studies. In a synthetic literature review, various databases such as PubMed, Scopus, Web of Science, and the Database of Polish Scientific Journals were queried to select relevant articles concerning azulene. The conclusions drawn from the thematic analysis of the studies emphasize the multifaceted pharmacological actions of azulene and its derivatives including their anti-inflammatory properties, potential anticancer effects, photoprotective abilities, alleviation of itching, management of atopic dermatitis, and treatment of erectile dysfunction. However, there are certain limitations associated with the application of unmodified azulene on the skin, particularly related to photodecomposition and the generation of reactive oxygen species under UV radiation. These effects, in turn, necessitate further research on the safety of azulene and azulene-derived substances, especially regarding their long-term use and potential application in phototherapy. The authors of this work emphasize the necessity of conducting further preclinical and clinical studies to fully understand the mechanisms of action. Incorporating azulene and its derivatives into the therapy of dermatological disorders may represent an innovative approach, thereby opening new treatment avenues for patients.
这篇科学文章专注于蓝烯及其衍生物在皮肤科疾病治疗中的作用，介绍了最新的实验室和临床研究以及进一步研究的前景。在综合文献综述中，查询了 PubMed、Scopus、Web of Science 和波兰科学期刊数据库等各种数据库，以选择与蓝烯有关的相关文章。对研究的主题分析得出的结论强调了蓝烯及其衍生物的多方面药理作用，包括其抗炎特性、潜在的抗癌作用、光保护能力、缓解瘙痒、特应性皮炎的管理以及勃起功能障碍的治疗。然而，在皮肤上应用未经修饰的蓝烯存在一些局限性，特别是与光分解以及在紫外线辐射下产生活性氧有关。这些影响反过来又需要进一步研究蓝烯和蓝烯衍生物质的安全性，特别是关于它们的长期使用和在光疗中的潜在应用。本文作者强调有必要进行进一步的临床前和临床研究，以充分了解其作用机制。将蓝烯及其衍生物纳入皮肤科疾病的治疗可能代表一种创新方法，从而为患者开辟新的治疗途径。
