de Marneffe M, Van Thiel E, Ewalenko M, Mols P, Naeije N, Bernard R, Englert M
Acta Cardiol. 1985;40(2):183-98.
Ten patients with acute myocardial infarction (AMI) underwent coronarographic studies before, immediately after and ten days after an intravenous infusion of 1 500 000 I.U. streptokinase (STK). Mean time between onset of symptoms to initiation of STK infusion was 03 hours 34 minutes. Occlusion of the infarct-related vessel was present in all of them and successful thrombolysis was obtained in 8 of the patients. Systemic fibrinolytic activity was present in 9 patients, one of whom required a transfusion of blood because of severe bleeding. At ventriculography, the global left ventricular ejection fraction and the regional ventricular ejection fraction, whatever the area involved, showed no significant improvement 10 days after the procedure. This suggests that high-dose intravenous STK in AMI, although causing an effective thrombolysis, does not seem to improve early myocardial function.
10例急性心肌梗死（AMI）患者在静脉输注150万国际单位链激酶（STK）之前、输注后即刻以及输注后10天接受了冠状动脉造影研究。症状发作至开始输注STK的平均时间为3小时34分钟。所有患者均存在梗死相关血管闭塞，其中8例患者溶栓成功。9例患者出现全身纤溶活性，其中1例因严重出血需要输血。心室造影显示，无论涉及哪个区域，术后10天整体左心室射血分数和局部心室射血分数均无显著改善。这表明，AMI患者静脉输注大剂量STK虽然能有效溶栓，但似乎并不能改善早期心肌功能。
