维生素 D 可减轻纤维结构不良衍生细胞的纤维性特征，促进向骨细胞表型转化。

Vitamin D Attenuates Fibrotic Properties of Fibrous Dysplasia-Derived Cells for the Transit towards Osteocytic Phenotype.

机构信息

Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.

Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

出版信息

Int J Mol Sci. 2024 May 1;25(9):4954. doi: 10.3390/ijms25094954.

DOI:10.3390/ijms25094954

PMID:38732172

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11084186/

Abstract

Fibrous dysplasia (FD) poses a therapeutic challenge due to the dysregulated extracellular matrix (ECM) accumulation within affected bone tissues. In this study, we investigate the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25(OH)D) in managing FD by examining its effects on FD-derived cells in vitro. Our findings demonstrate that 1,25(OH)D treatment attenuates the pro-fibrotic phenotype of FD-derived cells by suppressing the expression of key pro-fibrotic markers and inhibiting cell proliferation and migration. Moreover, 1,25(OH)D enhances mineralization by attenuating pre-osteoblastic cellular hyperactivity and promoting maturation towards an osteocytic phenotype. These results offer valuable insights into potential treatments for FD, highlighting the role of 1,25(OH)D in modulating the pathological properties of FD-derived cells.

摘要

纤维发育不良（FD）由于受影响的骨组织内细胞外基质（ECM）的失调积聚而带来治疗上的挑战。在本研究中，我们通过研究 1,25-二羟维生素 D3（1,25（OH）D）对体外 FD 衍生细胞的影响，探讨其在管理 FD 中的治疗潜力。我们的研究结果表明，1,25（OH）D 通过抑制关键的促纤维化标志物的表达以及抑制细胞增殖和迁移，减轻 FD 衍生细胞的促纤维化表型。此外，1,25（OH）D 通过减轻前成骨细胞的过度活跃并促进向成骨细胞表型的成熟来促进矿化。这些结果为 FD 的潜在治疗方法提供了有价值的见解，强调了 1,25（OH）D 在调节 FD 衍生细胞的病理特性中的作用。