Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico.
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico.
Nutrients. 2024 Apr 25;16(9):1275. doi: 10.3390/nu16091275.
The aim of the present study was to evaluate depressive-like, anxiety-like, and perseverative-like behaviors in a binge eating model. Juvenile Wistar rats, using the binge eating model, were compared to caloric restriction, induced stress, and control groups. Rats of the induced stress group presented binge-like behaviors in standard food intake in the second cycle of the experiment when compared to the caloric restriction group and the binge eating model group. Depressive-like behavior was observed in the binge eating model group with longer immobility time ( < 0.001) and less swim time ( < 0.001) in comparison to the control group. Anxiety-like behavior was observed by shorter duration of burying latency in the binge eating model group when compared to the induced stress group ( = 0.04) and a longer duration of burying time when compared to the control group ( = 0.02). We observed perseverative-like behavior by the binge model group, who made more entries to the new arm ( = 0.0004) and spent a longer time in the new arm when compared to the control group ( = 0.0001). Our results show differences in behaviors between the groups of rats studied. These results suggest that calorie restriction-refeeding, along with stress, may lead to depressive-like, anxiety-like, and perseverative-like behavioral changes in male Wistar rats.
本研究旨在评估暴食模型中的抑郁样、焦虑样和持续行为。与热量限制、诱导应激和对照组相比，使用暴食模型的幼年 Wistar 大鼠。与热量限制组和暴食模型组相比，诱导应激组的大鼠在实验的第二个周期中表现出标准食物摄入的暴食样行为。与对照组相比，暴食模型组表现出抑郁样行为，其不动时间更长（<0.001），游泳时间更少（<0.001）。与诱导应激组相比（=0.04），暴食模型组的埋首潜伏期更短，与对照组相比（=0.02），埋首时间更长，表明存在焦虑样行为。我们观察到持续行为，暴食模型组在新臂的进入次数更多（=0.0004），在新臂中的时间更长（=0.0001）。我们的研究结果表明，各组大鼠之间存在行为差异。这些结果表明，热量限制-再喂养，加上应激，可能导致雄性 Wistar 大鼠出现抑郁样、焦虑样和持续行为变化。
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