多巴胺受体亚型：体内功能相互作用的生化证据
Dopamine receptor subtypes: in vivo biochemical evidence for functional interaction.
作者信息
Saller C F, Salama A I
出版信息
Eur J Pharmacol. 1985 Feb 26;109(2):297-300. doi: 10.1016/0014-2999(85)90435-2.
PMID:3873343
Abstract
SKF 38393, a selective D-1 dopamine (DA) agonist, enhanced the ability of spiperone, a D-2 antagonist, to increase rat striatal DA metabolite concentrations. Conversely, SKF 38393 reduced the abilities of pergolide and LY 171555, D-2 agonists, to decrease striatal DA metabolite concentrations. These findings are discussed in terms of a possible functional interaction between D-1 and D-2 DA receptors.
摘要
SKF 38393，一种选择性D-1多巴胺（DA）激动剂，增强了D-2拮抗剂螺哌隆提高大鼠纹状体DA代谢物浓度的能力。相反，SKF 38393降低了D-2激动剂培高利特和LY 171555降低纹状体DA代谢物浓度的能力。这些发现从D-1和D-2 DA受体之间可能的功能相互作用方面进行了讨论。
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