I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2024 Mar;176(5):631-635. doi: 10.1007/s10517-024-06082-3. Epub 2024 May 11.
We studied the influence of DMSO administered ad libitum with drinking water in concentrations of 0.01, 0.1, and 1% for 4 and 6 weeks on pain sensitivity, motor coordination, and myelin content in the corpus callosum of C57BL/6 mice. After 6-week administration, DMSO in all studied concentrations decreased myelin content in the corpus callosum. Moreover, 4-week administration of 0.1% DMSO and 6-week administration of 1% DMSO increased the latency to fall in the rotarod test by 3.1 (p<0.05) and 5.1 (p<0.001) times, respectively. After 4-week administration of DMSO in concentrations of 0.01 and 0.1%, the latency of the tail flick response increased by 2.1 (p<0.05) and 1.8 times (p<0.001), respectively. Administration of DMSO in concentrations of 0.01 and 1% for 6 weeks led to a decrease of this parameter by 2.7 (p<0.05) and 3.8 times (p<0.01), respectively. Thus, DMSO in all studied concentrations decreased myelin content in the corpus callosum of C57BL/6 mice and modified motor coordination and pain sensitivity of animals.
我们研究了在 4 周和 6 周时自由饮用浓度为 0.01、0.1 和 1%的 DMSO 对 C57BL/6 小鼠痛觉敏感性、运动协调能力和胼胝体髓鞘含量的影响。在 6 周的给药后，所有研究浓度的 DMSO 均降低了胼胝体的髓鞘含量。此外，4 周时给予 0.1% DMSO 和 6 周时给予 1% DMSO 使在转棒试验中跌倒潜伏期分别增加了 3.1 倍（p<0.05）和 5.1 倍（p<0.001）。在给予 0.01 和 0.1% DMSO 4 周后，尾巴敲击反应的潜伏期分别增加了 2.1 倍（p<0.05）和 1.8 倍（p<0.001）。6 周时给予 0.01 和 1% DMSO 分别导致该参数降低了 2.7 倍（p<0.05）和 3.8 倍（p<0.01）。因此，所有研究浓度的 DMSO 均降低了 C57BL/6 小鼠胼胝体的髓鞘含量，并改变了动物的运动协调能力和痛觉敏感性。
