在白细胞介素-2存在下培养的人淋巴细胞中的自然杀伤样活性：获得对前列腺素E2或地塞米松介导抑制的抗性。
Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2: acquired resistance to prostaglandin E2- or dexamethasone-mediated suppression.
作者信息
Suzuki H, Yamashita N, Sato M, Iwata M, Maruyama M, Yano S
出版信息
Experientia. 1985 May 15;41(5):667-9. doi: 10.1007/BF02007711.
PMID:3873352
Abstract
The cytotoxic activity of human peripheral blood lymphocytes against the natural killer-sensitive target K562 was suppressed both by prostaglandin E2 and dexamethasone. On the other hand, cultured lymphoid cells propagated in the presence of interleukin-2 showed strong cytotoxic reactivity against K562 targets, and were resistant to prostaglandin E2- or dexamethasone-mediated suppression.
摘要
前列腺素E2和地塞米松均可抑制人外周血淋巴细胞对自然杀伤敏感靶细胞K562的细胞毒活性。另一方面，在白细胞介素-2存在的情况下培养的淋巴细胞对K562靶细胞表现出强烈的细胞毒反应性，并且对前列腺素E2或地塞米松介导的抑制具有抗性。
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