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在白细胞介素-2存在下培养的人淋巴细胞中的自然杀伤样活性：获得对前列腺素E2或地塞米松介导抑制的抗性。

Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2: acquired resistance to prostaglandin E2- or dexamethasone-mediated suppression.

作者信息

Suzuki H, Yamashita N, Sato M, Iwata M, Maruyama M, Yano S

出版信息

Experientia. 1985 May 15;41(5):667-9. doi: 10.1007/BF02007711.

DOI:10.1007/BF02007711
PMID:3873352
Abstract

The cytotoxic activity of human peripheral blood lymphocytes against the natural killer-sensitive target K562 was suppressed both by prostaglandin E2 and dexamethasone. On the other hand, cultured lymphoid cells propagated in the presence of interleukin-2 showed strong cytotoxic reactivity against K562 targets, and were resistant to prostaglandin E2- or dexamethasone-mediated suppression.

摘要

前列腺素E2和地塞米松均可抑制人外周血淋巴细胞对自然杀伤敏感靶细胞K562的细胞毒活性。另一方面，在白细胞介素-2存在的情况下培养的淋巴细胞对K562靶细胞表现出强烈的细胞毒反应性，并且对前列腺素E2或地塞米松介导的抑制具有抗性。

相似文献

1
Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2: acquired resistance to prostaglandin E2- or dexamethasone-mediated suppression.在白细胞介素-2存在下培养的人淋巴细胞中的自然杀伤样活性：获得对前列腺素E2或地塞米松介导抑制的抗性。
Experientia. 1985 May 15;41(5):667-9. doi: 10.1007/BF02007711.
2
The relative resistance of lymphokine activated killer cells to suppression by prostaglandins and glucocorticoids.淋巴因子激活的杀伤细胞对前列腺素和糖皮质激素抑制作用的相对抗性。
Prostaglandins Leukot Med. 1987 Jul;28(2):111-8. doi: 10.1016/0262-1746(87)90156-9.
3
Regulation of large granular lymphocytes and human T cell growth and function by recombinant interleukin 2. II. Acquisition of potent cytotoxic capabilities.重组白细胞介素2对大颗粒淋巴细胞及人T细胞生长和功能的调节。II. 获得强大的细胞毒性能力。
J Leukoc Biol. 1987 Sep;42(3):263-72. doi: 10.1002/jlb.42.3.263.
4
Cortisol at physiological concentrations and prostaglandin E2 are additive inhibitors of human natural killer cell activity.
Immunopharmacology. 1986 Apr;11(2):119-28. doi: 10.1016/0162-3109(86)90032-9.
5
Prostaglandin E2 inhibits the generation of phytohemagglutinin-activated killer activity in human peripheral blood lymphocytes.
Anticancer Res. 1986 Sep-Oct;6(5):1113-6.
6
Prostaglandin E2 depresses natural cytotoxicity by inhibiting interleukin-1 production by large granular lymphocytes.前列腺素E2通过抑制大颗粒淋巴细胞产生白细胞介素-1来降低自然细胞毒性。
Clin Exp Immunol. 1984 Aug;57(2):380-4.
7
Inhibition of cytotoxic responses by prostaglandin E2 in the presence of interleukin 2.在白细胞介素2存在的情况下，前列腺素E2对细胞毒性反应的抑制作用。
Cell Immunol. 1982 Sep 15;72(2):286-93. doi: 10.1016/0008-8749(82)90476-2.
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Activity and dexamethasone sensitivity of natural cytotoxic cell subpopulations.
Cell Immunol. 1982 Sep 1;72(1):113-21. doi: 10.1016/0008-8749(82)90288-x.
9
Characterization of natural cytotoxic effector cells isolated from rat liver.
Nat Immun Cell Growth Regul. 1987;6(3):150-60.
10
Effects of aging on the in vitro response of human lymphocytes to interleukin-2.衰老对人淋巴细胞白细胞介素-2体外反应的影响。
Jpn J Med. 1984 Aug;23(3):211-5. doi: 10.2169/internalmedicine1962.23.211.

引用本文的文献

1
Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes. A review of pre-clinical and clinical investigations.使用人重组白细胞介素-2和活化自体淋巴细胞对恶性胶质瘤进行免疫治疗。临床前和临床研究综述。
J Neurooncol. 1990 Apr;8(2):173-88. doi: 10.1007/BF00177842.

本文引用的文献

1
Suppression of the natural killer cell activity of murine spleen cell cultures by dexamethasone (41489).地塞米松对小鼠脾细胞培养物自然杀伤细胞活性的抑制作用(41489)
Proc Soc Exp Biol Med. 1982 Nov;171(2):146-50. doi: 10.3181/00379727-171-41489.
2
Natural cell-mediated cytotoxicity in vitro and inhibition of tumor growth in vivo by murine lymphoid cells cultured with T cell growth factor (TCGF).用T细胞生长因子（TCGF）培养的鼠淋巴细胞在体外的天然细胞介导细胞毒性及在体内对肿瘤生长的抑制作用。
Cancer Immunol Immunother. 1982;13(1):14-23. doi: 10.1007/BF00200195.
3
Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor.
在T细胞生长因子中培养的人淋巴细胞对新鲜的和培养的自体肿瘤的溶解作用。
Cancer Res. 1981 Nov;41(11 Pt 1):4420-5.
4
Antitumor reactivity in vitro and in vivo of lymphocytes from normal donors and cancer patients propagated in culture with T cell growth factor (TCGF).在含有T细胞生长因子（TCGF）的培养基中培养的正常供体和癌症患者淋巴细胞的体外和体内抗肿瘤反应性。
Eur J Cancer Clin Oncol. 1983 Jun;19(6):757-73. doi: 10.1016/0277-5379(83)90009-3.
5
Disappearance of the NK effect after explantation of lymphocytes and generation of similar nonspecific cytotoxicity correlated to the level of blastogenesis in activated cultures.淋巴细胞移出后NK效应消失，且产生了与活化培养物中母细胞生成水平相关的类似非特异性细胞毒性。
J Immunol. 1980 May;124(5):2458-63.
6
Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance.小鼠巨细胞病毒感染期间自然杀伤（NK）细胞扩增的遗传影响：与抗性模式的相关性
J Immunol. 1981 Mar;126(3):988-94.
7
Cyclic AMP as a mediator of prostaglandin E-induced suppression of human natural killer cell activity.环磷酸腺苷作为前列腺素E诱导人自然杀伤细胞活性抑制的介质。
J Immunol. 1983 Mar;130(3):1350-5.
8
Regulation of human natural killing. II. Protective effect of interferon on NK cells from suppression by PGE2.人类自然杀伤的调节。II. 干扰素对自然杀伤细胞免受前列腺素E2抑制的保护作用。
J Immunol. 1982 Oct;129(4):1742-7.
9
Two distinct human cloned T cell lines that exhibit natural killer-like and anti-human effector activities.两种不同的人类克隆T细胞系，具有自然杀伤样和抗人效应活性。
J Immunol. 1982 Apr;128(4):1749-52.
10
Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.