State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering, Yantai 264006, China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Colloids Surf B Biointerfaces. 2024 Jul;239:113956. doi: 10.1016/j.colsurfb.2024.113956. Epub 2024 May 8.
The early stages of osteoarthritis (OA) in the joints are typically characterized by two key factors: the dysfunction of articular cartilage lubrication and inflammation resulting from the excessive production of reactive oxygen species (ROS). Synthetic injectable macromolecular materials present great potential for preventing the progression of early OA. In this study, to mimic the excellent lubricity of brush-like aggregates found in natural synovial fluid, we develop a novel macromolecular biolubricant (CS-PS-DA) by integrating adhesion and hydration groups onto backbone of natural biomacromolecules. CS-PS-DA exhibits a strong affinity for cartilage surfaces, enabling the formation of a stable lubrication layer at the sliding interface of degraded cartilages to restore joint lubrication performance. In vitro results from ROS scavenging and anti-inflammatory experiments indicate the great advantage of CS-PS-DA to decrease the levels of proinflammatory cytokines by inhibiting ROS overproduction. Finally, in vivo rats OA model demonstrates that intra-cavitary injection of CS-PS-DA could effectively resist cartilage wear and mitigated inflammation in the joints. This novel biolubricant provides a new and timely strategy for the treatment of OA.
骨关节炎（OA）早期关节的特征通常有两个关键因素：关节软骨润滑功能障碍和活性氧（ROS）过度产生引起的炎症。合成可注射的高分子材料在预防早期 OA 进展方面具有很大的潜力。在这项研究中，为了模拟天然滑液中发现的刷状聚集物的优异润滑性，我们通过将粘附和水合基团整合到天然生物大分子的主链上，开发了一种新型的高分子生物润滑剂（CS-PS-DA）。CS-PS-DA 对软骨表面具有很强的亲和力，能够在降解软骨的滑动界面形成稳定的润滑层，从而恢复关节的润滑性能。ROS 清除和抗炎实验的体外结果表明，CS-PS-DA 通过抑制 ROS 的过度产生，降低促炎细胞因子的水平，具有很大的优势。最后，体内大鼠 OA 模型表明，腔内注射 CS-PS-DA 可以有效抵抗软骨磨损，减轻关节炎症。这种新型生物润滑剂为 OA 的治疗提供了一种新的及时策略。
