Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8640, Japan.
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8640, Japan.
Auris Nasus Larynx. 2024 Aug;51(4):696-702. doi: 10.1016/j.anl.2024.04.008. Epub 2024 May 10.
F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between F-FDG uptake and tumor metabolism- associated factors.
This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer.
GLS1 expression was found to be moderately correlated with SUVmax (p < 0.001, r = 0.51), whereas HK2 and VEGF expression were weakly correlated (p = 0.011, r = 0.28, p = 0.008, r = 0.29, respectively) and GLUT1 did not correlate with SUVmax (p = 0.62, r = 0.06).
Our findings suggest F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.
氟-18 脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG-PET/CT）是一种基于沃伯格效应的诊断成像方法，即癌细胞通过有氧糖酵解增加葡萄糖摄取。F-FDG-PET/CT 对甲状腺癌的诊断价值存在争议。然而，F-FDG 的摄取及其相应的最大标准化摄取值（SUVmax）预计能反映癌细胞的代谢状态。在本研究中，我们旨在确定 F-FDG 摄取与肿瘤代谢相关因素之间的关系。
这是一项单中心回顾性研究。在本研究中，我们比较了 41 例甲状腺癌患者的 SUVmax 与己糖激酶 2（HK2）、葡萄糖转运蛋白 1（GLUT1）、血管内皮生长因子（VEGF）和谷氨酰胺酶 1（GLS1）的表达。
GLS1 表达与 SUVmax 呈中度相关（p<0.001，r=0.51），而 HK2 和 VEGF 表达呈弱相关（p=0.011，r=0.28，p=0.008，r=0.29），GLUT1 与 SUVmax 无相关性（p=0.62，r=0.06）。
我们的研究结果表明，F-FDG PET/CT 反映了甲状腺癌中 GLS1 的表达，可用于选择适合 GLS1 抑制剂治疗的候选者。
