UROGIV Research Group, Universidad del Valle, Cali, Colombia.
UROGIV Research Group, Universidad del Valle, Cali, Colombia; Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia.
Actas Urol Esp (Engl Ed). 2024 Jul-Aug;48(6):427-436. doi: 10.1016/j.acuroe.2024.05.002. Epub 2024 May 9.
Bladder cancer (BC) is the seventh most common cancer worldwide. Not every infection ends as cancer, although the HPV-induced carcinogenesis is a complex process consequence of inflammation. To determine the association between human papillomavirus (HPV) and the diagnosis of bladder cancer.
We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.
We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63-6.66; I2 = 40%).
HPV is currently associated with the diagnosis of bladder cancer.
膀胱癌（BC）是全球第七大常见癌症。并非每一次感染都会发展成癌症，尽管 HPV 引起的癌变是炎症导致的复杂过程。为了确定人乳头瘤病毒（HPV）与膀胱癌诊断之间的关联。
我们根据 Cochrane 和 PRISMA 建议进行了系统评价。我们从建库开始至今在 EMBASE、Medline（Ovid）和 Cochrane 中央对照试验注册库（CENTRAL）中进行了检索。我们纳入了病例对照研究。基于 QUADAS2 对偏倚风险进行了评估。我们进行了随机效应 Meta 分析。
我们对 14 项研究进行了定性和定量分析。偏倚风险主要较低。我们最终发现 HPV 的存在与膀胱癌诊断之间存在很强的关联（OR 4.18，95%CI 2.63-6.66；I2=40%）。
目前 HPV 与膀胱癌的诊断相关。
