Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Operating Room, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ageing Res Rev. 2024 Jul;98:102323. doi: 10.1016/j.arr.2024.102323. Epub 2024 May 9.
Oxidative stress is one of the main driving mechanisms of intervertebral disc degeneration(IDD). Oxidative stress has been associated with inflammation in the intervertebral disc, cellular senescence, autophagy, and epigenetics of intervertebral disc cells. It and the above pathological mechanisms are closely linked through the common hub reactive oxygen species(ROS), and promote each other in the process of disc degeneration and promote the development of the disease. This reveals the important role of oxidative stress in the process of IDD, and the importance and great potential of IDD therapy targeting oxidative stress. The efficacy of traditional therapy is unstable or cannot be maintained. In recent years, due to the rise of materials science, many bioactive functional materials have been applied in the treatment of IDD, and through the combination with traditional drugs, satisfactory efficacy has been achieved. At present, the research review of antioxidant bioactive materials in the treatment of IDD is not complete. Based on the existing studies, the mechanism of oxidative stress in IDD and the common antioxidant therapy were summarized in this paper, and the strategies based on emerging bioactive materials were reviewed.
氧化应激是椎间盘退行性变（IDD）的主要驱动机制之一。氧化应激与椎间盘炎症、细胞衰老、自噬和椎间盘细胞的表观遗传学有关。它与上述病理机制通过共同的中心活性氧（ROS）紧密联系，并在椎间盘退变过程中相互促进，促进疾病的发展。这揭示了氧化应激在 IDD 过程中的重要作用，以及针对氧化应激的 IDD 治疗的重要性和巨大潜力。传统疗法的疗效不稳定或无法维持。近年来，由于材料科学的兴起，许多生物活性功能材料已应用于 IDD 的治疗中，并通过与传统药物结合，取得了满意的疗效。目前，抗氧化生物活性材料在治疗 IDD 中的研究综述并不完整。基于现有的研究，本文总结了 IDD 中氧化应激的机制和常见的抗氧化治疗方法，并综述了基于新兴生物活性材料的策略。
