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冠心病的磷脂生物标志物。

Phospholipid biomarkers of coronary heart disease.

作者信息

Morita Shin-Ya

机构信息

Department of Pharmacotherapeutics, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

出版信息

J Pharm Health Care Sci. 2024 May 11;10(1):23. doi: 10.1186/s40780-024-00344-y.

DOI:10.1186/s40780-024-00344-y
PMID:38734675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11088770/
Abstract

Coronary heart disease, also known as ischemic heart disease, is induced by atherosclerosis, which is initiated by subendothelial retention of lipoproteins. Plasma lipoproteins, including high density lipoprotein, low density lipoprotein (LDL), very low density lipoprotein, and chylomicron, are composed of a surface monolayer containing phospholipids and cholesterol and a hydrophobic core containing triglycerides and cholesteryl esters. Phospholipids play a crucial role in the binding of apolipoproteins and enzymes to lipoprotein surfaces, thereby regulating lipoprotein metabolism. High LDL-cholesterol is a well-known risk factor for coronary heart disease, and statins reduce the risk of coronary heart disease by lowering LDL-cholesterol levels. In contrast, the relationships of phospholipids in plasma lipoproteins with coronary heart disease have not yet been established. To further clarify the physiological and pathological roles of phospholipids, we have developed the simple high-throughput assays for quantifying all major phospholipid classes, namely phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol, phosphatidylglycerol + cardiolipin, and sphingomyelin, using combinations of specific enzymes and a fluorogenic probe. These enzymatic fluorometric assays will be helpful in elucidating the associations between phospholipid classes in plasma lipoproteins and coronary heart disease and in identifying phospholipid biomarkers. This review describes recent progress in the identification of phospholipid biomarkers of coronary heart disease.

摘要

冠心病，又称缺血性心脏病，由动脉粥样硬化引发，而动脉粥样硬化始于脂蛋白在内皮下的潴留。血浆脂蛋白，包括高密度脂蛋白、低密度脂蛋白（LDL）、极低密度脂蛋白和乳糜微粒，由一个包含磷脂和胆固醇的表面单层以及一个包含甘油三酯和胆固醇酯的疏水核心组成。磷脂在载脂蛋白和酶与脂蛋白表面的结合中起关键作用，从而调节脂蛋白代谢。高LDL胆固醇是冠心病的一个众所周知的危险因素，他汀类药物通过降低LDL胆固醇水平来降低冠心病风险。相比之下，血浆脂蛋白中的磷脂与冠心病之间的关系尚未确立。为了进一步阐明磷脂的生理和病理作用，我们开发了简单的高通量检测方法，使用特定酶和荧光探针的组合来定量所有主要磷脂类别，即磷脂酰胆碱、磷脂酰乙醇胺、磷脂酰丝氨酸、磷脂酸、磷脂酰肌醇、磷脂酰甘油+心磷脂和鞘磷脂。这些酶促荧光检测方法将有助于阐明血浆脂蛋白中磷脂类别与冠心病之间的关联，并有助于识别磷脂生物标志物。本综述描述了冠心病磷脂生物标志物识别方面的最新进展。

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