The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Hengshan Road 910, Shanghai, 200030, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Sci Rep. 2024 May 11;14(1):10800. doi: 10.1038/s41598-024-61119-x.
Preterm labor, a condition associated with various risk factors such as a history of prior preterm birth (PTB) and multiple pregnancies, has recently seen an increasing focus on its potential link with dyslipidemia. This study aims to investigate the relationship between dyslipidemia in expectant mothers and the risks of PTB. We studied 6963 mothers who gave birth at the International Peace Maternal and Child Health Hospital of Shanghai Jiaotong University School of Medicine in 2020, among which, 437 women had PTB. We extracted clinical and lipid data from electronic records, using multivariable logistic regression and restricted cubic spline models to explore the link between lipid concentrations (by quartiles) in pregnancy stages and PTB risk. The PTB rate was 6.3%. Early pregnancy in the PTB group showed elevated ApoA, ApoB, CHOL, LDL, and TG levels compared to controls (all P < 0.05). Late pregnancy showed no notable lipid differences. Multivariable analysis revealed elevated ApoA, TG, higher age, BMI ≥ 28 kg/m, hypertension, assisted reproductive technology and gestational diabetes as PTB risk factors (all P < 0.05). After adjustments, higher ApoA, ApoB, CHOL and TG levels correlated with increased PTB risk. Using the lowest quartile, the adjusted ORs for early pregnancy's highest quartile of ApoA, ApoB, CHOL and TG were 1.348, 1.442, 1.442 and 2.156, respectively. Our findings indicate that dyslipemia in early pregnancy, including elevated levels of ApoA, ApoB, CHOL and TG, are associated with PTB. Managing lipid abnormalities during pregnancy may help reduce the risk of PTB.
早产是一种与多种风险因素相关的疾病，如既往早产史和多胎妊娠等。最近，人们越来越关注早产与血脂异常之间的潜在联系。本研究旨在探讨孕妇血脂异常与早产风险之间的关系。我们研究了 2020 年在上海交通大学医学院国际和平妇幼保健院分娩的 6963 位母亲，其中 437 位母亲发生早产。我们从电子病历中提取了临床和血脂数据，采用多变量逻辑回归和限制性立方样条模型来探讨妊娠各阶段血脂浓度（按四分位数）与早产风险之间的关系。早产率为 6.3%。与对照组相比，早产组的早期妊娠 ApoA、ApoB、CHOL、LDL 和 TG 水平升高（均 P<0.05）。晚期妊娠血脂无明显差异。多变量分析显示，ApoA、TG 升高、年龄较大、BMI≥28kg/m2、高血压、辅助生殖技术和妊娠期糖尿病是早产的危险因素（均 P<0.05）。调整后，ApoA、ApoB、CHOL 和 TG 水平升高与早产风险增加相关。使用最低四分位数，早期妊娠 ApoA、ApoB、CHOL 和 TG 最高四分位数的调整 OR 分别为 1.348、1.442、1.442 和 2.156。我们的研究结果表明，包括 ApoA、ApoB、CHOL 和 TG 水平升高在内的早孕期血脂异常与早产相关。在孕期管理血脂异常可能有助于降低早产风险。
