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瞬时受体电位香草酸亚型 1（TRPV1）通道在三阴性乳腺癌发生发展中的功能和作用机制。

Function and mechanism of action of the TRPV1 channel in the development of triple-negative breast cancer.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2024 May 11;56(7):957-962. doi: 10.3724/abbs.2024068.

DOI:10.3724/abbs.2024068
PMID:38734935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11322878/
Abstract

Transient receptor potential channel subfamily vanilloid 1 (TRPV1) is a member of the transient receptor potential family of nonselective cationic transmembrane channel proteins that are involved in the regulation of calcium homeostasis. It is expressed in various tumor types and has been implicated in the regulation of cancer growth, metastasis, apoptosis, and cancer-related pain. TRPV1 is highly expressed in triple-negative breast cancer (TNBC), and both its agonists and antagonists may exert anti-cancer effects. In this review, we provide an overview of the effect of TRPV1 on TNBC development and its influence on immunotherapy in an attempt to facilitate the development of future treatment strategies.

摘要

瞬时受体电位通道香草素 1 型（TRPV1）是瞬时受体电位家族的一员，属于非选择性阳离子跨膜通道蛋白，参与钙稳态的调节。它在各种肿瘤类型中表达，并与肿瘤生长、转移、凋亡和癌相关疼痛的调节有关。TRPV1 在三阴性乳腺癌（TNBC）中高表达，其激动剂和拮抗剂都可能发挥抗癌作用。在这篇综述中，我们概述了 TRPV1 对 TNBC 发展的影响及其对免疫治疗的影响，以期为未来的治疗策略的发展提供帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/832d/11322878/61bf977aa5a5/ABBS-2023-569-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/832d/11322878/61bf977aa5a5/ABBS-2023-569-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/832d/11322878/61bf977aa5a5/ABBS-2023-569-t1.jpg

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本文引用的文献

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Immunomodulatory Prodrug Micelles Imitate Mild Heat Effects to Reshape Tumor Microenvironment for Enhanced Cancer Immunotherapy.免疫调节前药胶束模拟温和热效应重塑肿瘤微环境以增强癌症免疫治疗。
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Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.
纳米颗粒介导的 TRPV1 通道阻断通过热休克因子 1 调节增强癌症热免疫治疗。
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Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis.癌症中活性氧调节背后的分子机制：肿瘤发生增强与细胞凋亡之间的平衡行为。
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[Analysis on cancer incidence and mortality attributed to human papillomavirus infection in China, 2016].《2016年中国因人类乳头瘤病毒感染所致癌症的发病率与死亡率分析》
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