The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark..
The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Reprod Biomed Online. 2024 Jul;49(1):103862. doi: 10.1016/j.rbmo.2024.103862. Epub 2024 Feb 6.
Are serum progesterone concentrations on the day of modified natural cycle (mNC) frozen blastocyst transfer (FET) without luteal phase support (LPS) associated with clinical pregnancy rate (CPR)?
Data were collected between January 2019 and October 2022 as a sub-study of an ongoing randomized controlled trial assessing pregnancy outcomes in mNC-FET. The sub-study included all women (n = 209) randomized to mNC-FET without LPS at the time of data extraction. Participants were aged 18-41 years, had regular menstrual cycles and underwent mNC-FET treatment with single-blastocyst transfer. Associations between the serum progesterone concentration on the day of blastocyst transfer and CPR, pregnancy rate and pregnancy loss rate (PLR) were examined between groups with low and higher progesterone concentrations using the 25th and 10th percentiles as cut-offs. Multivariate logistic regression analyses were performed to adjust for potential confounding factors.
Progesterone concentrations on the day of blastocyst transfer in mNC-FET without LPS ranged from 4.9 to 91.8 nmol/l, with the 25th and 10th percentiles at 29.0 nmol/l and 22.5 nmol/l, respectively. Serum progesterone concentrations did not differ between women with or without a clinical pregnancy (mean [SD] 38.5 [14.0] versus 36.8 [12.4] nmol/l; P = 0.350). Furthermore, the CPR, pregancy rate and PLR were similar in women with low or high progesterone concentrations when using the 25th or the 10th progesterone percentile as cut-off. Multivariate regression analyses showed no association between progesterone concentrations and CPR.
No association was found between progesterone concentration on the day of blastocyst transfer and pregnancy outcome in women undergoing mNC-FET without progesterone LPS.
在没有黄体支持（LPS）的改良自然周期（mNC）冷冻胚胎移植（FET）当天的血清孕酮浓度是否与临床妊娠率（CPR）相关？
数据收集于 2019 年 1 月至 2022 年 10 月期间，作为一项正在进行的随机对照试验评估 mNC-FET 妊娠结局的子研究。该子研究包括在数据提取时随机分配至 mNC-FET 且无 LPS 的所有女性（n=209）。参与者年龄在 18-41 岁之间，月经周期规律，接受 mNC-FET 治疗，单个胚胎移植。使用第 25 和第 10 百分位数作为截断值，比较低孕酮浓度组和高孕酮浓度组之间的胚胎移植日血清孕酮浓度与 CPR、妊娠率和妊娠丢失率（PLR）之间的关系。使用多变量逻辑回归分析调整潜在的混杂因素。
在没有 LPS 的 mNC-FET 中，胚胎移植日的孕酮浓度范围为 4.9-91.8nmol/L，第 25 和第 10 百分位数分别为 29.0nmol/L 和 22.5nmol/L。有临床妊娠和无临床妊娠的女性之间的血清孕酮浓度没有差异（均值[标准差]分别为 38.5[14.0]nmol/L 和 36.8[12.4]nmol/L；P=0.350）。此外，当使用第 25 或第 10 个孕酮百分位数作为截断值时，低孕酮浓度或高孕酮浓度的女性的 CPR、妊娠率和 PLR 相似。多变量回归分析显示孕酮浓度与 CPR 之间无关联。
在没有 LPS 的 mNC-FET 中，胚胎移植日的孕酮浓度与女性的妊娠结局之间没有发现关联。
