National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.
National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, Taiwan; School of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Environ Res. 2024 Aug 15;255:119130. doi: 10.1016/j.envres.2024.119130. Epub 2024 May 11.
This study aims to assess the specific PM-bound metallic elements that contribute to asthma emergency department visits by using a case-crossover study design.
This study analyzed data from 11,410 asthma emergency department visits as case group and 22,820 non-asthma onset dates occurring one week and two weeks preceding the case day as controls from 2017 to 2020. PM monitoring data and 35 PM.-bound metallic elements from six different regions in Taiwan were collected. Conditional logistic regression models were used to assess the relationship between asthma and PM-bound metallic elements.
Our investigation revealed a statistically significant risk of asthma emergency department visits associated with PM exposure at lag 0, 1, 2, and 3 during autumn. Additionally, PM-bound hafnium (Hf), thallium (Tl), rubidium (Rb), and aluminum (Al) exhibited a consistently significant positive correlation with asthma emergency department visits at lags 1, 2, and 3. In stratified analyses by area, age, and sex, PM-bound Hf showed a significant and consistent correlation.
This study provides evidence of PM-bound metallic elements effects in asthma exacerbations, particularly for Hf. It emphasizes the importance of understanding the origins of these metallic elements and pursuing emission reductions to mitigate regional health risks.
本研究旨在通过病例交叉研究设计，评估导致哮喘急诊就诊的特定与 PM 结合的金属元素。
本研究分析了 2017 年至 2020 年期间，11410 例哮喘急诊就诊作为病例组和 22820 例非哮喘发作日期（在病例日之前一周和两周）作为对照组的数据。收集了来自台湾六个不同地区的 PM 监测数据和 35 种与 PM 结合的金属元素。采用条件逻辑回归模型评估哮喘与 PM 结合的金属元素之间的关系。
我们的研究表明，秋季滞后 0、1、2 和 3 时 PM 暴露与哮喘急诊就诊存在统计学显著的风险关联。此外，PM 结合的铪（Hf）、铊（Tl）、铷（Rb）和铝（Al）在滞后 1、2 和 3 时与哮喘急诊就诊呈一致显著正相关。在按地区、年龄和性别分层分析中，PM 结合的铪显示出显著且一致的相关性。
本研究提供了 PM 结合的金属元素在哮喘恶化中的作用的证据，特别是对于 Hf。它强调了了解这些金属元素的来源并追求减排以减轻区域健康风险的重要性。
