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急性症状性孤立性腹主动脉夹层 - 临床特征、结局和性别差异。

Acute Symptomatic Isolated Abdominal Aortic Dissection - Clinical Characteristics, Outcome, and Sex Differences.

机构信息

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Södersjukhuset, Stockholm, Sweden.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Ann Vasc Surg. 2024 Sep;106:61-70. doi: 10.1016/j.avsg.2024.02.026. Epub 2024 May 10.

Abstract

BACKGROUND

Acute isolated abdominal aortic dissection (IAAD) is a rare condition and treatment recommendations are lacking. Most previous studies included both symptomatic and asymptomatic patients. The aims were to determine the proportion of IAAD among patients with acute type B aortic dissection as well as to describe patient characteristics, radiological findings, and frequency of early and late complications and to explore sex differences.

METHODS

This was a retrospective cohort study including all patients hospitalized with acute symptomatic IAAD in Stockholm County during 2012-2021.

RESULTS

A total of 277 patients with acute type B aortic dissection were identified, of whom 10% (n = 28/277) had acute IAAD. Median age was 56 years and 43% (n = 12/28) were women. Hypertension was diagnosed in 46% (n = 13/28) prior to admission. At onset, abdominal pain was the predominant complaint (93%, n = 26/28) and 93% (n = 26/28) were hypertensive on admission. The suprarenal aorta was involved in 39% (n = 11/28) and at least 1 of the iliac arteries in 50% (n = 14/28). All but 1 patient had uncomplicated IAAD (96%, n = 27/28). One patient presented with aortic rupture, treated with open surgical repair. Among patients with primarily uncomplicated IAAD, 7% eventually developed chronic complications (n = 2/27). Median maximum aortic diameter at 1-year follow-up was 21 mm (interquartile range 17-28). Only 1 patient had an aortic diameter exceeding 30 mm. None of the patients died during follow-up; median follow-up was 3.0 years (interquartile range 2-8).

CONCLUSIONS

Early and late complications are rare in patients with acute symptomatic IAAD and a conservative approach with antihypertensive treatment and surveillance in uncomplicated cases seems reasonable.

摘要

背景

急性孤立性腹主动脉夹层(IAAD)是一种罕见的疾病,缺乏治疗建议。大多数先前的研究都包括有症状和无症状的患者。目的是确定急性 B 型主动脉夹层患者中 IAAD 的比例,并描述患者特征、影像学发现以及早期和晚期并发症的频率,并探讨性别差异。

方法

这是一项回顾性队列研究,包括 2012 年至 2021 年期间在斯德哥尔摩县因急性症状性 IAAD 住院的所有患者。

结果

共确定 277 例急性 B 型主动脉夹层患者,其中 10%(n=28/277)为急性 IAAD。中位年龄为 56 岁,43%(n=12/28)为女性。入院前诊断出高血压的占 46%(n=13/28)。发病时,腹痛是主要主诉(93%,n=26/28),入院时 93%(n=26/28)患者血压升高。肾上主动脉受累占 39%(n=11/28),至少 1 条髂动脉受累占 50%(n=14/28)。除 1 例患者外,其余患者均为单纯性 IAAD(96%,n=27/28)。1 例患者出现主动脉破裂,行开放手术修复。在单纯性 IAAD 为主的患者中,7%最终出现慢性并发症(n=2/27)。1 年随访时的最大主动脉直径中位数为 21mm(四分位距 17-28)。仅 1 例患者的主动脉直径超过 30mm。随访期间无患者死亡;中位随访时间为 3.0 年(四分位距 2-8)。

结论

急性症状性 IAAD 患者的早期和晚期并发症罕见,对于单纯性病例,采用降压治疗和监测的保守治疗方法似乎是合理的。

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